Proteinprotein interaction detection: methods and analysis

VS Rao, K Srinivas, GN Sujini… - International journal of …, 2014 - Wiley Online Library
… transduction pathways. Recent developments have also led to the construction … networks
having all the protein-protein interactions using computational methods for signaling pathways

Cell‐to‐cell and type‐to‐type heterogeneity of signaling networks: insights from the crowd

…, Single Cell Signaling in Breast Cancer … - Molecular systems …, 2021 - embopress.org
… Further, we encouraged participants to incorporate external data and resources of prior
knowledge, such as pathways and proteinprotein interaction databases, in their models. …

Tissue-specific alternative splicing remodels protein-protein interaction networks

JD Ellis, M Barrios-Rodiles, R Colak, M Irimia, TH Kim… - Molecular cell, 2012 - cell.com
… These proteins participate in significantly more interactions in protein-protein interaction (PPI)
networks than other proteins. Using LUMIER, an automated PPI assay, we observe that …

Proteinprotein interaction in insulin signaling and the molecular mechanisms of insulin resistance

A Virkamäki, K Ueki, CR Kahn - The Journal of clinical …, 1999 - Am Soc Clin Investig
… although the insulin signaling network is complex, modern cell biology and biochemistry are
… the insulin signal transduction pathways into an understanding of how these pathways can …

The membrane environment can promote or suppress bistability in cell signaling networks

SM Abel, JP Roose, JT Groves, A Weiss… - The Journal of …, 2012 - ACS Publications
… , increased concentration promotes bistability through enhanced proteinprotein binding,
while lower mobility and membrane-enhanced spatiotemporal correlations suppress bistability. …

Dissecting the specificity of protein-protein interaction in bacterial two-component signaling: orphans and crosstalks

A Procaccini, B Lunt, H Szurmant, T Hwa, M Weigt - PloS one, 2011 - journals.plos.org
… In this study, we dissect the specificity of protein-protein interactions governing two-component
signaling (TCS… wiring diagram towards a system-level understanding of cellular signaling. …

[HTML][HTML] Heat shock proteins in cell signaling and cancer

BJ Lang, TL Prince, Y Okusha, H Bunch… - … (BBA)-Molecular Cell …, 2022 - Elsevier
… Many cell signaling events are mediated by the chemical … in cell signaling events with a focus
on oncogenic signaling. We also … cell signaling events that may link PTMs with the cellular

Techniques for the analysis of protein-protein interactions in vivo

S Xing, N Wallmeroth, KW Berendzen… - Plant physiology, 2016 - academic.oup.com
… and catabolism, almost all cellular functions depend on and are executed by complex
protein-protein interactions (PPIs). While complete biochemical pathways and even some protein …

Human cancer protein-protein interaction network: a structural perspective

G Kar, A Gursoy, O Keskin - PLoS computational biology, 2009 - journals.plos.org
… related human protein-protein interfaces and the topological properties of the cancer network.
… of six interaction networks: 1) the human protein-protein interaction network, (PIN), 2) the …

Identifying functional modules in proteinprotein interaction networks: an integrated exact approach

MT Dittrich, GW Klau, A Rosenwald, T Dandekar… - …, 2008 - academic.oup.com
… Motivation: With the exponential growth of expression and proteinprotein interaction (PPI) …
in PPI networks, sharing common cellular function beyond the scope of classical pathways, …