Dissecting the mechanisms of immune checkpoint therapy

P Sharma, JP Allison - Nature Reviews Immunology, 2020 - nature.com
… H 1 cell subset. Blockade of TGFβ plus immune checkpoint therapy led to T H 1 CD4 + T
cell responses and the clonal expansion of CD8 + T cells in bone tumours, which led to …

The distribution of T‐cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid …

P Williams, S Basu, G Garcia‐Manero, CS Hourigan… - Cancer, 2019 - Wiley Online Library
… of immune checkpoint markers on different T-cell subsets, we observed that PD1 and OX40
emerged as checkpoints … -positive and OX40-positive T cells in BMAs from patients with AML …

Beyond immune checkpoint blockade: emerging immunological strategies

SP Kubli, T Berger, DV Araujo, LL Siu… - Nature reviews Drug …, 2021 - nature.com
… roles of the T reg cell and T H 17 cell subsets during tumour angiogenesis, which need to
be clarified 85,86,87 . The increased expression of CTLA4 by these cell subsets might suggest …

Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients

SM Toor, K Murshed, M Al-Dhaheri, M Khawar… - Frontiers in …, 2019 - frontiersin.org
Blockade of inhibitory immune checkpoints (ICs) is a … T regulatory cell (Treg)-related markers
on CD4 + T cell subsets in … different CD4 + T cell subsets and the clinicopathologic features …

Soluble immune checkpoints and T-cell subsets in blood as biomarkers for resistance to immunotherapy in melanoma patients

D Machiraju, M Wiecken, N Lang, I Hülsmeyer… - …, 2021 - Taylor & Francis
… We evaluated the association between soluble immune checkpoints and peripheral T cell
subsets with the response to anti-PD1 or anti-CTLA4 plus anti-PD1 ICI treatments in patients …

[HTML][HTML] Rethinking immune checkpoint blockade:'Beyond the T cell'

X Liu, GD Hogg, DG DeNardo - Journal for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
… success of immune checkpoint inhibitors has highlighted the central role of the immune system
in … However, research on immune checkpoint blockade has largely been framed with the …

Not all immune checkpoints are created equal

A De Sousa Linhares, J Leitner… - Frontiers in …, 2018 - frontiersin.org
… in regulating T cells and other cells of the immune system. … potential of the emerging immune
checkpoints, there are still … major inhibitory immune checkpoints expressed on T cells. It …

[HTML][HTML] Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma

A Lechner, H Schlößer, SI Rothschild, M Thelen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… T-cell subsets and expression of immune checkpoint molecules in head and neck squamous
cell … In this study, we provide the first comprehensive analysis of multiple T-cell subsets and …

Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer

Y Zhang, H Chen, H Mo, X Hu, R Gao, Y Zhao, B Liu… - Cancer cell, 2021 - cell.com
… of combining chemotherapy with checkpoint inhibitors is still not very clear. We utilize
single-cell RNA- and ATAC-sequencing to examine the immune cell dynamics in 22 patients with …

Costimulatory molecules and immune checkpoints are differentially expressed on different subsets of dendritic cells

C Carenza, F Calcaterra, F Oriolo, C Di Vito… - Frontiers in …, 2019 - frontiersin.org
… from inhibitory checkpoint molecules on DC … subsets is fragmentary. Therefore, in this study,
we investigated the expression of three immune checkpoints on peripheral blood DC subsets