Dissecting the mechanisms of immune checkpoint therapy
P Sharma, JP Allison - Nature Reviews Immunology, 2020 - nature.com
… H 1 cell subset. Blockade of TGFβ plus immune checkpoint therapy led to T H 1 CD4 + T
cell responses and the clonal expansion of CD8 + T cells in bone tumours, which led to …
cell responses and the clonal expansion of CD8 + T cells in bone tumours, which led to …
The distribution of T‐cell subsets and the expression of immune checkpoint receptors and ligands in patients with newly diagnosed and relapsed acute myeloid …
… of immune checkpoint markers on different T-cell subsets, we observed that PD1 and OX40
emerged as checkpoints … -positive and OX40-positive T cells in BMAs from patients with AML …
emerged as checkpoints … -positive and OX40-positive T cells in BMAs from patients with AML …
Beyond immune checkpoint blockade: emerging immunological strategies
… roles of the T reg cell and T H 17 cell subsets during tumour angiogenesis, which need to
be clarified 85,86,87 . The increased expression of CTLA4 by these cell subsets might suggest …
be clarified 85,86,87 . The increased expression of CTLA4 by these cell subsets might suggest …
Immune Checkpoints in Circulating and Tumor-Infiltrating CD4+ T Cell Subsets in Colorectal Cancer Patients
Blockade of inhibitory immune checkpoints (ICs) is a … T regulatory cell (Treg)-related markers
on CD4 + T cell subsets in … different CD4 + T cell subsets and the clinicopathologic features …
on CD4 + T cell subsets in … different CD4 + T cell subsets and the clinicopathologic features …
Soluble immune checkpoints and T-cell subsets in blood as biomarkers for resistance to immunotherapy in melanoma patients
D Machiraju, M Wiecken, N Lang, I Hülsmeyer… - …, 2021 - Taylor & Francis
… We evaluated the association between soluble immune checkpoints and peripheral T cell
subsets with the response to anti-PD1 or anti-CTLA4 plus anti-PD1 ICI treatments in patients …
subsets with the response to anti-PD1 or anti-CTLA4 plus anti-PD1 ICI treatments in patients …
[HTML][HTML] Rethinking immune checkpoint blockade:'Beyond the T cell'
X Liu, GD Hogg, DG DeNardo - Journal for immunotherapy of …, 2021 - ncbi.nlm.nih.gov
… success of immune checkpoint inhibitors has highlighted the central role of the immune system
in … However, research on immune checkpoint blockade has largely been framed with the …
in … However, research on immune checkpoint blockade has largely been framed with the …
Not all immune checkpoints are created equal
A De Sousa Linhares, J Leitner… - Frontiers in …, 2018 - frontiersin.org
… in regulating T cells and other cells of the immune system. … potential of the emerging immune
checkpoints, there are still … major inhibitory immune checkpoints expressed on T cells. It …
checkpoints, there are still … major inhibitory immune checkpoints expressed on T cells. It …
[HTML][HTML] Characterization of tumor-associated T-lymphocyte subsets and immune checkpoint molecules in head and neck squamous cell carcinoma
A Lechner, H Schlößer, SI Rothschild, M Thelen… - Oncotarget, 2017 - ncbi.nlm.nih.gov
… T-cell subsets and expression of immune checkpoint molecules in head and neck squamous
cell … In this study, we provide the first comprehensive analysis of multiple T-cell subsets and …
cell … In this study, we provide the first comprehensive analysis of multiple T-cell subsets and …
Single-cell analyses reveal key immune cell subsets associated with response to PD-L1 blockade in triple-negative breast cancer
… of combining chemotherapy with checkpoint inhibitors is still not very clear. We utilize
single-cell RNA- and ATAC-sequencing to examine the immune cell dynamics in 22 patients with …
single-cell RNA- and ATAC-sequencing to examine the immune cell dynamics in 22 patients with …
Costimulatory molecules and immune checkpoints are differentially expressed on different subsets of dendritic cells
C Carenza, F Calcaterra, F Oriolo, C Di Vito… - Frontiers in …, 2019 - frontiersin.org
… from inhibitory checkpoint molecules on DC … subsets is fragmentary. Therefore, in this study,
we investigated the expression of three immune checkpoints on peripheral blood DC subsets…
we investigated the expression of three immune checkpoints on peripheral blood DC subsets…
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