Regeneration of spinal cord connectivity through stem cell transplantation and biomaterial scaffolds

H Katoh, K Yokota, MG Fehlings - Frontiers in cellular neuroscience, 2019 - frontiersin.org
… neural stem cells, neural progenitor cells, and neural precursor cells are, strictly speaking,
different cell populations, we also believe that most cell transplants are a mix of these cells. …

Transplanting neural progenitor cells to restore connectivity after spinal cord injury

I Fischer, JN Dulin, MA Lane - Nature Reviews Neuroscience, 2020 - nature.com
… Neuroepithelial cells transplanted into the adult spinal cord showed poor survival, but …
on improving connectivity with NPC transplants, it is important to note that cell transplantation

Stem cell transplantation for spinal cord injury repair

P Lu - Progress in Brain Research, 2017 - Elsevier
cord is stem cell transplantation. Just like the typical clinical stem cell transplant that often
refers to bone marrow transplant for … cord, with an emphasis on axonal growth and connectivity

… axon connectivity across a spinal cord transection in rats treated with epidural stimulation and motor training combined with olfactory ensheathing cell transplantation

MA Thornton, MD Mehta, TT Morad, KL Ingraham… - Experimental …, 2018 - Elsevier
… When we examined the injury sites of our spinal rats for evidence of cell transplant survival
we found that neither OECs nor FBs survived to 7 months post-transplantation. OECs are …

Neural stem cells: promoting axonal regeneration and spinal cord connectivity

CM de Freria, E Van Niekerk, A Blesch, P Lu - Cells, 2021 - mdpi.com
cord after cell transplantation. In adult rats, neuronal and non-neuronal cell transplants
In the 1970s, studies using transplantation of cerebellar and non-cultured neocortical tissue …

Axonal growth and connectivity from neural stem cell grafts in models of spinal cord injury

P Lu, K Kadoya, MH Tuszynski - Current opinion in neurobiology, 2014 - Elsevier
… Human iPS cell-derived NSCs have been transplanted into … growth and connectivity from
human iPS cell grafts has not … derived from iPS cells into mid-cervical spinal cord lesion sites in …

Grafted neural progenitors integrate and restore synaptic connectivity across the injured spinal cord

JF Bonner, TM Connors, WF Silverman… - Journal of …, 2011 - Soc Neuroscience
… BDNF–green fluorescent protein (GFP) or GFP lentiviral vector was injected into the dorsal
column nuclei 7 d after injury and cell transplantation. Animals were divided into groups …

Cell transplantation therapy for spinal cord injury

P Assinck, GJ Duncan, BJ Hilton, JR Plemel… - Nature …, 2017 - nature.com
… of the mechanisms whereby these cells promote functional … spinal cord injury, will be important
to make cell transplantation a … (b) Transplanted cells may improve the connectivity through …

Neural tranplantation in the spinal cord of adult rats: Conditions, survival, cytology and connectivity of the transplants

GD Das - Journal of the neurological sciences, 1983 - Elsevier
cord itself, or the use of inappropriate embryonic neural tissues as transplants, or inadequate
techniques of transplantation… related to transplantation of neural tissues in the spinal cord in …

[HTML][HTML] Long-distance growth and connectivity of neural stem cells after severe spinal cord injury

P Lu, Y Wang, L Graham, K McHale, M Gao, D Wu… - Cell, 2012 - cell.com
… Graft exhibits excellent viability and connectivity with caudal aspect of host spinal cord; thus,
re-transection retains healthy graft but eliminates entry of host inputs from above lesion site. …