… of pyruvate kinase M2 (PKM2) in several cell types, … cellular processes, particularly for
cancer cells. Interestingly, PKM2 in cancer cells has a lower activity in converting PEP to pyruvate, …

… and protein kinase activity. Here we review the structure, function, and regulation of pyruvate
kinase and discuss how these properties enable regulation of PKM2 for cell proliferation …

… blocks pyruvate kinase activity (Wang et al., 2014a). Decreased PKM2 pyruvate kinase activity
… and the ability of cells to synthesize DNA and progress the cell cycle, suggesting that an …

… In ascites hepatoma cells (AH 130), which are believed to originate from liver parenchymal
cells, all the pyruvate kinase was type M and its specific activity was markedly elevated. In …

… ) or used for the synthesis of cell building blocks (nearly inactive dimeric form)… pyruvate
kinase M2 expression by different transcription factors as well as the regulation of pyruvate kinase …

… Accordingly, in proliferating cells, the pyruvate kinase equilibrium is regulated at the cost of
… of the various cells and tissues. Pyruvate kinase type L is the characteristic pyruvate kinase …

… cancer types. However, in this study, PK isoform expression among the different cell types
within the particular tissues, ie the tubules system in the kidney or the different cell types in the …

… Phosphoenolpyruvate, the substrate of pyruvate kinase is the most energy rich cellular … In
accordance, in yeast cells, the overexpression of pyruvate kinase leads to an inhibition of cell …

… molecule, oral activator of red cell pyruvate kinase, AG-348, is currently in clinical trials (NCT02476916,
NCT03548220, NCT03559699). This drug activates wild-type PK in vitro as well …

… types of Charon 4A human genomic libraries were screened with a 32P-labeled cDNA for rat
M,-type pyruvate kinase [… HeLa cells contained the M2-type PK mRNA (data not shown), we …