… related to intratumor heterogeneity during tumor evolution. We also discuss experimental
approaches that are commonly used to infer intratumor heterogeneity and describe how these …

… Thus, the distinct responses of TICs versus non-TICs to standard chemoradiation therapies
highlights the clinical importance of cellular heterogeneity and motivates further investigation …

… as cell-to-cell phenotypic heterogeneity may initiate key steps in microbial evolution of drug
… Here, we study how stochastic transitions between cellular states influence evolutionary …

… of heterogeneity in patient samples, as well as the current state of understanding of these
categories in breast cancer, from cell to cell, across … Efforts to characterize tumor heterogeneity …

… Intrapatient heterogeneity is responsible for generating subpopulations of cancer cells which
undergo clonal evolution with time. Tumour heterogeneity develops also as a consequence …

… Given the apparent key role of the delayed IκBε feedback loop for the generation of cell-to-cell
heterogeneity, we tested the effect of altering the timing of the IκBε delay on the emergent …

… analyses [14] provide insight into the dynamics of evolutionary adaptation. We review how
… -heterogeneity and macro-heterogeneity, thereby unravelling the fundamental evolutionary …

… Here, we discuss the molecular and cellular heterogeneity of breast cancer, the impact of
this heterogeneity on practical breast cancer classification, and the challenges for personalized …

… cellular properties promises to enhance our understanding of development and disease.
The basis of cell-to-cell heterogeneity in … , expression heterogeneity could arise from cell-to-cell …

… This reversible plasticity is captured by mathematical models that incorporate between-cell
heterogeneity through continuous phenotypic variables. Such models have the benefit of …