… This review discusses the increasingly sophisticated molecular mechanisms being
discovered by which mammalian glycosylation governs physiology and contributes to disease. …

… cell fate. Finally, we briefly discuss novel physiological outputs of the UPR in different cell
types and organs and its possible involvement in the development of human diseases. …

The endoplasmic reticulum (ER) is a multifunctional organelle critical for the proper folding
and assembly of secreted and transmembrane proteins. Perturbations of ER functions cause …

… known as a cellular mechanism of adaptation to environmental stresses. However, increasing
evidence suggests that the UPR could be central in the control of cellular functions under …

… Current understanding of ER stress and the resultant cellular response mechanisms are
providing a gateway for drug discovery and therapeutic strategies in human disease. However, …

… Here, however, we would like to highlight the few known cellular mechanisms which might
be responsible for some of the effects seen in vivo. Most recently, it has been shown for the …

… cellular mechanisms of PA-induced health benefits. (1) What are the dose-response
parameters (intensity, duration, frequency) that maximize responses over time? (2) How do dose-…

The endothelium is an expansive spatially distributed organ. 1 Endothelial cells participate
in a large number of physiological processes including the control of vasomotor tone, the …

… apoptosis will lead to diseases characterized by abnormal cell number. Although apoptosis
… mechanisms of parenchymal renal cell apoptosis, especially tubular cells, in kidney injury. …

… We review the cellular and physiological mechanisms responsible for the regulation of
blood flow in the retina and choroid in health and disease. Due to the intrinsic light sensitivity of …