The inflammasomes in health and disease: from genetics to molecular mechanisms of autoinflammation and beyond

C Conforti-Andreoni, P Ricciardi-Castagnoli… - Cellular & molecular …, 2011 - nature.com
Nucleotide-binding oligomerization domain (NOD)-containing protein-like receptors (NLRs)
are a recently discovered class of innate immune receptors that play a crucial role in …

Shared molecular and cellular mechanisms of premature ageing and ageing-associated diseases

N Kubben, T Misteli - Nature Reviews Molecular Cell Biology, 2017 - nature.com
… in cell and molecular mechanisms that are common between human premature ageing
diseases … characterized premature ageing diseases and exhibits a wide range of cellular, tissue …

Microbes in gastrointestinal health and disease

AS Neish - Gastroenterology, 2009 - Elsevier
… , deployed, and optimized complex immune mechanisms that monitor and control this
microbial ecosystem. These cellular mechanisms have homeostatic roles beyond the traditional …

Myeloperoxidase: molecular mechanisms of action and their relevance to human health and disease

BS Van der Veen, MPJ de Winther… - Antioxidants & redox …, 2009 - liebertpub.com
… in cell signaling and cellcelldiseases. In this article, our knowledge pertaining to the
biologic role of MPO and its downstream effects and mechanisms of action in health and disease

Polyphenols and human health: prevention of disease and mechanisms of action

D Vauzour, A Rodriguez-Mateos, G Corona… - Nutrients, 2010 - mdpi.com
… The interaction of polyphenols with cellular signaling pathways involved in chronic disease.
… The interaction of polyphenols with cellular signaling pathways involved in chronic disease. …

Inflammasomes and their roles in health and disease

M Lamkanfi, VM Dixit - Annual review of cell and developmental …, 2012 - annualreviews.org
Inflammasomes are a set of intracellular protein complexes that enable autocatalytic
activation of inflammatory caspases, which drive host and immune responses by releasing …

Pulmonary immune cells in health and disease: polymorphonuclear neutrophils

Y Sibille, FX Marchandise - European Respiratory Journal, 1993 - Eur Respiratory Soc
… Among the mechanisms implicated in the removal of PMNs, apoptosis or programmed cell
death appears to play a central role. Apoptosis is characterized by morphological changes, …

Reactive nitrogen species: molecular mechanisms and potential significance in health and disease

MC Martinez, R Andriantsitohaina - Antioxidants & redox signaling, 2009 - liebertpub.com
… RNS, highlighting the potential cellular targets and the expected cell effects. Next, we give …
living cell, and finally, we look at the consequences of RNS in health, including diseases such …

Inflammasomes in health and disease

T Strowig, J Henao-Mejia, E Elinav, R Flavell - nature, 2012 - nature.com
… downregulation either through secreted factors or cellcell interactions. Examples of these
… In summary, the host has evolved distinct mechanisms to regulate inflammasome activation …

Iron transport & homeostasis mechanisms: their role in health & disease

SS Nadadur, K Srirama, A Mudipalli - Indian Journal of Medical …, 2008 - journals.lww.com
… A comprehensive discussion on metal transport and homeostasis mechanisms and their
role in health and disease is beyond the scope of this review article. To have a focused …