Red blood cell homeostasis: mechanisms and effects of microvesicle generation in health and disease

JKF Leal, MJW Adjobo-Hermans… - Frontiers in physiology, 2018 - frontiersin.org
Red blood cells (RBCs) generate microvesicles to remove damaged cell constituents such
as oxidized hemoglobin and damaged membrane constituents, and thereby prolong their …

Molecular and cellular mechanisms for Alzheimer's disease: understanding APP metabolism

Y Zhang, H Xu - Current molecular medicine, 2007 - ingentaconnect.com
… We will review current knowledge of the secretases (-, -, and secretases) involved in APP
processing and various molecular and cellular mechanisms underlying intracellular trafficking …

Roles and mechanisms of exosomal non-coding RNAs in human health and diseases

C Li, YQ Ni, H Xu, QY Xiang, Y Zhao, JK Zhan… - Signal transduction and …, 2021 - nature.com
diseases. In this review, we comprehensively discuss the underlying regulatory mechanisms
of exosomes in human diseaseshealth and diseases, including cancers, metabolic diseases

Skeletal muscle in health and disease

J Morgan, T Partridge - Disease models & mechanisms, 2020 - journals.biologists.com
… of the cellular mechanisms that govern the growth and regeneration of skeletal muscle,
and highlight the defects in satellite cell function that give rise to muscular dystrophies. …

Roles of PPARs in health and disease

S Kersten, B Desvergne, W Wahli - Nature, 2000 - nature.com
… LDL, a critical event in foam cell formation. A feed-forward mechanism has been proposed
whereby oxidized fatty acids that enter the cell through oxidized LDL can activate PPARγ, …

Role of caveolae and caveolins in health and disease

AW Cohen, R Hnasko, W Schubert… - Physiological …, 2004 - journals.physiology.org
… the mechanisms by which caveolae and caveolins participate in human disease processes.
… may exploit caveolar potocytosis as a mechanism for cellular invasion. In the same auspice, …

Cellular mechanisms of resistance to chronic oxidative stress

Y Sagara, R Dargusch, D Chambers, J Davis… - Free Radical Biology …, 1998 - Elsevier
… and, ultimately, apoptotic cell death. Several HT-22 subclones that are 10-fold resistant to
exogenous glutamate were isolated and the mechanisms involved in resistance characterized. …

Reactive oxygen species in health and disease

AA Alfadda, RM Sallam - BioMed research international, 2012 - Wiley Online Library
… , and cellular mechanisms involved in mediating the ROS actions offer promising venues as
they propose novel potential therapeutic agents for the ROS-linked diseases. Few examples …

Endothelial dysfunction as a cellular mechanism for vascular failure

T Hirase, K Node - American Journal of Physiology-Heart …, 2012 - journals.physiology.org
… Accordingly, the endothelial dysfunction that is induced by atherogenic stimuli is considered
to play crucial roles as a cellular mechanism in the development of vascular failure. …

Organ and tissue fibrosis: Molecular signals, cellular mechanisms and translational implications

R Weiskirchen, S Weiskirchen, F Tacke - Molecular aspects of medicine, 2019 - Elsevier
… or Gli1 positive mesenchymal stem cell-like cells, to a transition of various cell types into …
principles of fibrogenic molecular signals and cellular mechanisms in various organs - such …