… that lead proteins to lose their native structure. In the second and third parts we describe
the molecular and cellular mechanisms that are associated with protein misfolding in disease. …

… , known as unfolded protein responses (UPRs), including induction/activation of antioxidant
… of the cell. Second, we will discuss the mechanisms by which misfolded proteins lead to the …

… mechanism of formation and the structural features of protein … The complexity of protein
aggregation allows proteins to give … the mechanisms of aggregation of several proteins for which …

… for protein aggregation diseases. There is a need to study the protein misfolding phenomenon
… some of the worst kinds of human ailments related to protein misfolding and aggregation. …

… protein thiol groups, represents one mechanism contributing to NO-induced protein misfolding
… that NO contributes to protein misfolding via S-nitrosylating protein-disulfide isomerase or …

… cell is said to experience ER stress, a result of the accumulation of unfolded or misfolded
proteins in … Here we discuss the causes of ER stress and the mechanisms by which cells elicit a …

… part of the cellular management of misfolded proteins is their … 26), protein aggregation in
the cell differs fundamentally from … sequester surplus and misfolded proteins into transient or …

… of how intrinsic protein conformational propensities are modulated by physiological and
pathological interactions in the cell to shape protein misfolding and aggregation pathology. …

… these misfolding diseases. Keeping the above views in mind in the current review, we have
comprehensively discussed the different mechanisms underlying protein misfolding thereby …

… proteins within the lipid bilayer. Many other examples of the mutually beneficial intersection
of cell biology … Here, I will review our current understanding of the cell biological mechanisms …