… Furthermore, mutations on some of the genes coding for proteins involved in the cellular
metabolism, such as rafDI (encoding ADP-l-glycero-d-mannose-6-epimerase) or gapA (…

… The horizontal gene transfer step may be not necessary if the cellular metabolic
mechanisms affected have a sufficiently broad specificity to cope with novel substrates such as …

… As such, perturbations to bacterial metabolic homeostasis are significant consequences of
… antibiotic efficacy in the context of bacterial metabolism: (1) antibiotics alter the metabolic …

… A large body of evidence exists on mutations that confer antibiotic resistance, but we know
only relatively little about how such mutations affect cellular metabolism, either directly or …

… Antibiotic resistant bacteria (ARB) can be conferred by antibiotic resistance genes (ARGs), …
withstand the antibacterial or bactericidal effects of antibiotics (Woodford and Ellington, 2007; …

… (46) Genome and metabolome data of several clinical isolates of pathogenic strains have
shed more light on mechanisms of antibiotic resistance and revealed new cellular pathways as …

… targets, enzymatic modification of intracellular targets, enzymatic transformation of
antibiotics, and the implementation of cellular metabolism reactions. The main mechanisms of …

… in cellular metabolism, in which the diverse array of metabolic … to elucidate metabolic
aspects of antibiotic resistance. … to detect mutations in metabolism-related genes. Constant …

… metabolic consequences of antibiotic resistance, the genomic and transcriptomic profiles of
an amoxicillin-resistant … in cell wall maintenance, DNA metabolic processes, cellular stress …

… A central, yet unsolved question is how resistance evolution affects cell growth … resistance
mutants from their effects on cell metabolism. The model maps metabolic effects of resistance …