Cellular senescence in aging and age-related disease: from mechanisms to therapy

BG Childs, M Durik, DJ Baker, JM Van Deursen - Nature medicine, 2015 - nature.com
Cellular senescence, a process that imposes … to aging and age-related disease, and it is
an attractive target for therapeutic exploitation. A wealth of information about senescence in …

Cellular senescence in aging primates

U Herbig, M Ferreira, L Condel, D Carey, JM Sedivy - Science, 2006 - science.org
… Whether cellular senescence contributes to organismal aging has been controversial. … aging
baboons for telomere dysfunction, a recently discovered biomarker of cellular senescence (1…

A multidimensional systems biology analysis of cellular senescence in aging and disease

RA Avelar, JG Ortega, R Tacutu, EJ Tyler, D Bennett… - Genome biology, 2020 - Springer
… , cellular senescence genes are strongly conserved in mammals but not in invertebrates.
We also build cellular senescence … Clusters in the networks are enriched for cell cycle and …

Aging, cellular senescence, and cancer

J Campisi - Annual review of physiology, 2013 - annualreviews.org
cellular senescence—links multiple pathologies of aging, both degenerative and hyperplastic.
Cellular senescence is unlikely to explain all aging … number of aging pathologies have …

Epigenetic regulation of cellular senescence and aging

C Sidler, O Kovalchuk, I Kovalchuk - Frontiers in genetics, 2017 - frontiersin.org
… underlie cellular senescence and promote aging at the cellular level. We will also examine
… that underlie immunosenescence as an example for an aging system. Cellular Senescence

Mitochondrial dysfunction in cell senescence and aging

S Miwa, S Kashyap, E Chini… - The Journal of clinical …, 2022 - Am Soc Clin Investig
… Mitochondrial dysfunction and cell senescence are hallmarks of aging … of cellular senescence
and figures prominently in multiple feedback loops that induce and maintain the senescent

[HTML][HTML] Sirtuin signaling in cellular senescence and aging

SH Lee, JH Lee, HY Lee, KJ Min - BMB reports, 2019 - ncbi.nlm.nih.gov
aging. This article reviews the evidences and controversies regarding the roles of Sirtuin on
cellular senescence … compounds that increase the cellular level of nicotinamide dinucleotide. …

Characterization of cellular senescence in aging skeletal muscle

X Zhang, L Habiballa, Z Aversa, YE Ng, AE Sakamoto… - Nature Aging, 2022 - nature.com
… evidence for cellular senescence as a hallmark and potentially tractable mediator of SkM
aging. … strongly suggest that cellular senescence is a core feature of SkM aging and a potential …

Emerging roles of extracellular vesicles in cellular senescence and aging

M Takasugi - Aging cell, 2018 - Wiley Online Library
… enhanced in the context of cellular senescence or aging, it has been shown that telomere
shortening, which is involved in replicative senescence and aging, increases expression level …

Cellular senescence in aging lungs and diseases

A Aghali, ML Koloko Ngassie, CM Pabelick… - Cells, 2022 - mdpi.com
… of cellular senescence relevant to different aspects of the structure and function of aging lungs
… We review the influence of mitochondrial dysfunction in the context of cellular senescence