… , the focus is on bone hemostasis and its dysregulation with aging. The major physiological
changes with aging in bone and the role of cellular senescence in contributing to age related …

… Thus, telomere attrition impairs osteoblast differentiation and perhaps contributes to skeletal
aging due to increased cellular senescence of skeletal MSCs. However, similar to the direct …

… Multiple signalling pathways are involved in regulating cellular senescence in bone and
bone marrow microenvironments. Targeted SnCs alleviate age-related degenerative diseases. …

… cell senescence in the context of age-related bone loss by broadly discussing aging mechanisms
in bone, … bone aging that may be contributed by senescent cells, mechanisms by which …

… underlying bone cell senescence during aging and how they could be targeted to reduce
the negative impact of senescence in the aging skeleton. © 2014 American Society for Bone …

… Aging is associated with increased cellular senescence, which is hypothesized to drive the
… Here we investigate a role for senescent cells in age-related bone loss through multiple …

… mediate senescence cell-cycle arrest and initiate SASP. We also summarize recent literature
on the role of cellular senescence in maintaining bone homeostasis and mediating age-…

… Cellular senescence is therefore a defining feature of age-related musculoskeletal disorders,
and targeted elimination of these cells has emerged recently as a promising therapeutic …

… , including p16 Ink4a , p21 Cip1 , or p53, or in the SASP panel used in our aging studies (28)
in osteocyte-enriched bone samples from mice 2 months after ovariectomy (or orchiectomy) …

… Similarly, the accumulation of senescent bone cells and their … of cellular senescence during
aging can serve as potential therapeutic targets to contain morbidity and improve the bone …