… In this review, we ask questions about the role of senescent brain cells in brain plasticity
and cognitive functions impairments and how senolytics can improve them. We will discuss …

… a senescent state remains unclear. In this review we examine recent data that suggest that
cellular senescence plays a role in brain … , it is clear that brain cells in both AD and PD share …

… SASP from senescent brain cells. Although there are still many unanswered questions
involving brain cell senescence, the ability to critically test the idea that senescent cells can cause …

… senescent cells, which are characterized by sustained cell cycle arrest and production of a
distinct senescence-… Cells with features of senescence have been detected in the context of …

… evidence of cellular senescence in neurons and glial cells and … for the first time, evidence of
senescence in neurons and glia in … The processes that lead to loss of brain cells with normal …

… In the following sections, we review studies reporting senescence in post-mitotic brain cells.
We evaluate the methods used by key studies and compare them to our pre-defined criteria …

… On the one hand, it would be necessary to understand if the senescence that is observed
in brain cells during various neuropathologies is part of their etiology and supports their …

… of cellular senescence in brain and thus may be useful to study the role of cellular senescence
in … We measured the levels of cellular senescence markers in the brains of P301S(PS19), …

… The senescence of brain cells is a major risk factor for … Thus, cellular senescence can serve
as a primary therapeutic … the concept of cellular senescence, its role in the aging brain, and …

… Thus, cellular senescence accumulation in the peripheral tissues, in both age-related and
… We hypothesized that peripheral cellular senescence contributes to brain aging and age-…