… mechanisms through which senescent brain cells contribute to … cells, but not all cells
expressing p16 Ink4a are senescent and not all p16 Ink4a -positive SCs are present in the brain. …

… The question arises whether senescence-induced inflammation … of cellular senescence
as a driver of the aging phenotype, and discuss the current evidence that connects senescence …

… reduce NFTs and pharmacologically clear senescent cells. Our results indicate that NFTs
induce cellular senescence in transgenic mice and postmortem human brain tissue. We also …

… between vascular cell senescence and BBB integrity in vivo, we analyzed brain microvessels
in BubR1 H/H mice. Because it has already been shown that senescent cells accumulate …

… of cell senescence by performing double and triple staining in sections of the temporal lobe
and brain … driving cellular senescence contribute to dystrophic transformation of microglia. …

… to DNA damage or other cellular stresses. We discuss evidence for endothelial cell senescence
in ageing and cardiovascular disease, and how CEC senescence may contribute to age-…

… are not cleared then the accumulation of senescent cells becomes greater with time, … as a
pro-senescence stimulus and induces cellular senescence in different brain cell types, leading …

… into cellular senescence and its influence in disease. Recent studies have explored evidence
for senescence in brain cells … is significant evidence for endothelial cell senescence in age-…

… Glioma is the most common primary brain tumor and is often associated with treatment
resistance and … , both of which induce cellular senescence—a tumor suppression mechanism. …

… In MS, accelerated cellular senescence may drive disease … blood-brain barrier integrity
and ultimately neurodegeneration. Here we discuss the evidence linking cellular senescence to …