… In this review we will discuss the role of senescent cells in brain pathologies, in particular
age-associated neurodegenerative diseases such as Alzheimer's disease, Parkinson's …

… length in brain cells is still unclear and under debate. … Several studies show that
cellular senescence is tightly … between cellular senescence, telomere shortening, and AD. …

… With each cell division, telomeres progressively shorten until they reach a critical length, at
which point the cells enter cellular senescence. Microglia, a non-neuronal cell type residing …

… Several senolytic compounds with the capability to eliminate senescent cells have been …
of cellular senescence and discussed the evidence of senescence in various brain cell …

… of cellular senescence. In this manuscript, we review current knowledge of microglia in the
aging brain … an age-related decline in proliferative function as a result of cellular senescence. …

… On the basis of current understanding of the underlying mechanisms involved, we
hypothesize that there may be an inherent link between cellular senescence in the brain and the …

… Recent discoveries are redefining our view of cellular senescence as a trigger of tissue …
this, senescent cells arrest their own proliferation, recruit phagocytic immune cells and …

… Cellular senescence is a process in which cells change their characteristic … senescent
cells. Finally, we will examine their potential to directly eliminate these senescent brain cells. …

… brain aging is the decline in cognitive function. In addition, cellular senescence is a stable
state of cell … To investigate which cell types in the brain become senescent, we performed …

… on cellular senescence and the proinflammatory changes observed in the SASP of senescent
cells. … in astroglial cells in order to assess whether astrocytes in the aging brain express …