Aging is a prominent risk factor for cardiovascular diseases, which is the leading cause of
death around the world. Recently, cellular senescence has received potential attention as a
promising target in preventing cardiovascular diseases, including acute myocardial
infarction, atherosclerosis, cardiac aging, pressure overload-induced hypertrophy, heart
regeneration, hypertension, and abdominal aortic aneurysm. Here, we discuss the
mechanisms underlying cellular senescence and describe the involvement of senescent …

The aging process is associated with a loss of complexity in the dynamics of physiological
systems that reduce the ability to adapt to stress, causing frailty and/or age-related diseases.
At the cellular level, proliferative and/or oxidative-stress induced cell senescence associated
with a pro-inflammatory state may greatly contribute to age-associated impaired tissue and
organ functions. Senescence of endothelial and cardiac cells observed over normal aging,
appear to be accelerated in age-related diseases and in particular, in cardiovascular …