[HTML][HTML] Extracellular matrix dynamics as an emerging yet understudied hallmark of aging and longevity

C Statzer, JYC Park, CY Ewald - Aging and Disease, 2023 - ncbi.nlm.nih.gov
… molecular damage result in stem cell exhaustion, stem cell senescence, and elevated levels
… conserved kinase that acts at the nexus of the cell signals related to growth, survival, and …

Biological mechanisms of aging predict age‐related disease co‐occurrence in patients

HC Fraser, V Kuan, R Johnen, M Zwierzyna… - … Cell, 2022 - Wiley Online Library
… Highly ranked ARDs for cellular senescence included … , which are exacerbated by the
senescence-associated secretory … a complex nexus of failure of molecular and cellular processes, …

Relationship between gene expression associated with cellular senescence in cells from discarded wound dressings and wound healing: A retrospective cohort study

C Takizawa, Q Qin, D Haba, S Sasaki… - Journal of Tissue …, 2024 - Elsevier
… Pearson’s correlation coefficient was calculated between cellular senescence and SASP
expression. The relationship between the gene expression of cellular senescence and the …

Two-step senescence-focused cancer therapies

CJ Sieben, I Sturmlechner, B van de Sluis… - Trends in cell …, 2018 - cell.com
Cellular senescence refers to a molecular program activated in response to environmental
cues or stress including, but not limited to, the end of replicative lifespan/telomere erosion, …

[HTML][HTML] The interplay of vitamin D deficiency and cellular senescence in the pathogenesis of obesity-related co-morbidities

A Bima, B Eldakhakhny, D Nuwaylati, A Alnami… - Nutrients, 2021 - mdpi.com
cellular senescence. Obesity is a serious worldwide chronic health problem for all ages [1].
Cellular senescence induces a cell-… obesity, VDD, and cellular senescence and the possible …

[PDF][PDF] Inflammation and cellular senescence: potential contribution to chronic diseases and disabilities with aging

JL Kirkland - Public Policy and Aging Report, 2013 - afar.org
… Chronic inflammation, cellular senescence, or other fundamental aging mechanisms could
be at the nexus between chronological aging and many of the chronic diseases that are …

[HTML][HTML] Underlying mechanisms and treatment of cellular senescence-induced biological barrier interruption and related diseases

R Sun, J Feng, J Wang - Aging and Disease, 2024 - ncbi.nlm.nih.gov
… in cellular senescence and age-related diseases. In this review, we conclude that cellular
senescence is … We further outline the cellular pathways and mechanisms underlying barrier …

Cellular senescence as the key intermediate in tau-mediated neurodegeneration

AR Mendelsohn, JW Larrick - Rejuvenation Research, 2018 - liebertpub.com
nexus of inflammatory disease with the secretory-associated senescence phenotype (SASP)
of cellular senescence, … neurodegeneration involves induction of senescence in astrocytes, …

[HTML][HTML] Skeletal senescence with aging and type 2 diabetes

JN Farr - Endocrinology and Metabolism, 2023 - synapse.koreamed.org
… mechanisms that exist at the nexus of osteoporosis and T2D … momentum in recent years is
cellular senescence [9-11]. … -resident cell types become susceptible to cellular senescence

Aging, cellular senescence, and cancer

J Campisi - Annual review of physiology, 2013 - annualreviews.org
… at least partly linked by a common biological phenomenon: a cellular stress response known
as cellular senescence. The senescence response is widely recognized as a potent tumor …