… , cellular senescence, its role as a cellular response to stress and damage, and its known
and hypothesized relationships to cancer and degenerative … Cellular senescence suppresses …

… of cellular senescence in the neurodegenerative diseases … chronically, cellular aging and
degenerative diseases would … of cellular senescence in the neurodegenerative diseases AD, …

… Along with a general decline in overall health, most chronic degenerative human diseases
are inherently associated with increasing age. Age-associated cognitive impairments and …

… also decreased with progressive stages of degeneration. SA-β-Gal staining was not observed
in non-degenerative patients, unlike cells from degenerative discs, which did exhibit 10–12…

… models suggests that remyelination can protect demyelinated axons and even correlates
with greater age at death, whereas chronically demyelinated axons are prone to degeneration […

… sites of pathogenesis in many chronic diseases and conditions. The SASP can contribute to
… SASP, and effects of senescent cells. Cellular senescence is a cell fate that, like replication, …

… cells increasingly is recognized as a critical step in age-dependent tissue dysfunction and
is implicated in the pathogenesis of many degenerative diseases, including AD. There are …

… roles for senescence. We discuss how a primary role of cellular senescence is to contribute
to normal development, cell plasticity and tissue repair, as a dynamic and tightly regulated …

… senolytic’ drugs that kill senescent cells or inhibitors of the senescence-associated secretory
… evidence that cellular senescence has a causative role in multiple diseases associated with …

… cellular senescence as a trigger of tissue remodelling that acts during normal embryonic
development and upon tissue damage. To achieve this, senescent … senescence in each disease…