Living on a break: cellular senescence as a DNA-damage response

F D'adda Di Fagagna - Nature Reviews Cancer, 2008 - nature.com
… Oncogene activation also causes DDR activation and cellular senescence. Oncogene-… for
the involvement of the DDR in the control of cellular senescence. The DNA-damage response …

Cell senescence, DNA damage, and metabolism

R Shmulevich, V Krizhanovsky - Antioxidants & Redox Signaling, 2021 - liebertpub.com
… Recent Advances: Cellular metabolism plays a … cell senescence. In the past decade, our
knowledge about the interplay between cell signaling, cell metabolism, and cellular senescence

Human cell senescence as a DNA damage response

T Von Zglinicki, G Saretzki, J Ladhoff… - Mechanisms of ageing …, 2005 - Elsevier
… of senescence that are not induced by either DNA damage or … of SDFs is a marker for cellular
senescence. This immediately … cellular senescence, both within in vitro and in vivo settings. …

DNA damage, cellular senescence and organismal ageing: causal or correlative?

JH Chen, CN Hales, SE Ozanne - Nucleic acids research, 2007 - academic.oup.com
… stress and attenuate DNA damage contribute towards longevity. … oxidative damage levels of
macromolecules including DNA … role of DNA damage in cellular senescence and organismal …

Cellular senescence and DNA repair

Z Lou, J Chen - Experimental cell research, 2006 - Elsevier
… that cellular senescence could be triggered by DNA damage. In … DNA damage response
pathway. This review will discuss the link between DNA repair defects and cellular senescence. …

Crosstalk between chromatin state and DNA damage response in cellular senescence and cancer

G Sulli, R Di Micco, FA di Fagagna - Nature Reviews Cancer, 2012 - nature.com
… factors in the context of cellular senescence that is induced by … DNA damage
checkpoint-induced cell cycle arrest and the persistent cell cycle arrest that is typical of cellular

DNA damage response and cellular senescence in tissues of aging mice

C Wang, D Jurk, M Maddick, G Nelson… - Aging cell, 2009 - Wiley Online Library
… independent, DNA damage-induced senescence increases with … with the idea that cellular
senescence might be among the … DNA damage is a major factor to cause cellular senescence

DNA damage in telomeres and mitochondria during cellular senescence: is there a connection?

JF Passos, G Saretzki, T Von Zglinicki - Nucleic acids research, 2007 - academic.oup.com
… results in less telomeric damage and slower telomere shortening, … and telomeric DNA
damage during cellular senescence. … and telomeric DNA damage driving cellular senescence. …

The DNA damage signaling pathway connects oncogenic stress to cellular senescence

FA Mallette, G Ferbeyre - Cell cycle, 2007 - Taylor & Francis
… Several forms of DNA damage can be easily detected in cells as foci that accumulate …
the DNA damage foci found in senescent cells ODDI (oncogene‑induced DNA damage foci)…

[HTML][HTML] Depletion of SIRT6 causes cellular senescence, DNA damage, and telomere dysfunction in human chondrocytes

K Nagai, T Matsushita, T Matsuzaki, K Takayama… - Osteoarthritis and …, 2015 - Elsevier
DNA damage and telomere dysfunction resulted in subsequent DNA damage responses and
eventual cellular senescence… through which SIRT6 promotes DNA repair and protects from …