… cellular senescence as a … cellular senescence affects remyelination, and the putative benefits
to be drawn through the use of senolytic or senomorphic therapies targeting senescent cell …

… -cycle arrest may exhaust the regenerative capacities of adult progenitors, such as
oligodendrocyte progenitor cells (OPCs) responsible for myelin repair. In addition, CS along with …

… remyelination by differentiating into myelinating oligodendrocytes, a process highly
relevant to myelin repair in multiple sclerosis [113]. Although OPCs do not undergo replicative …

… Contrasting myelin damage through the generation of new … limit myelin damage early
after injury, whereas they lose their pro-resolving capacity and acquire a dystrophic “senescent-like…

… We hypothesized that the process of cellular aging called cellular senescence may contribute
to differences in support for myelination previously reported by NPCs derived from PPMS …

… In this review, we provide a current overview of the current knowledge on cellular
senescence and its role in neuroinflammatory disorders. For the latter, we focus on MS as a …

… Cellular senescence occurs both in vitro and in vivo (46) and it has … In this review, we will
describe cellular senescence in the … oligodendrocytes might decrease neuron myelination and …

… To induce cellular senescence, we added myelin debris as an external stressor to mimic the
… degradation of myelin under the pathological condition that contributes to the senescence of …

… use it to refer to ‘cellular senescence’, which is a specific function of cellular aging. This theory
of … Therefore, astrocytic senescence may contribute to reduced myelin production and a …

… OLs we monitored SA-β-galactosidase activity, a biomarker for cellular senescence. …
response, cellular senescence and SASP factors (Tables S1, S2 and S3). Interestingly, myelination-…