Cellular senescence is a homeostatic biological process characterized by a permanent state
of cell cycle arrest that can contribute to the decline of the regenerative potential and
function of tissues. The increased presence of senescent cells in different
neurodegenerative diseases suggests the contribution of senescence in the
pathophysiology of these disorders. Although several factors can induce senescence, DNA
damage, oxidative stress, neuroinflammation, and altered proteostasis have been shown to …

The senescence of brain cells has recently attracted great interest regarding its potentially
important role in brain aging and neurodegenerative diseases such as Alzheimer and
Parkinson diseases. From physiological aging to neurodegeneration, senescencelike
phenotypes are found in multiple subclasses of dividing and nondividing brain cells,
including glial cells, endothelial cells, neural stem cells, and neurons. These senescent cells
may co-opt cellular machineries to activate their secretosomes, contributing to …