… important in cellular senescence and tumor suppression in … ( 63–65 ) The case for Arf as
a tumor suppressor is perhaps … cellular senescence and tumor suppression in human cells. …

… cellular senescence. While apoptosis is a programmed cell death process, cellular senescence,
which is the focus of this article, is defined as irreversible cell cycle arrest. This process …

… key effectors of cellular senescence. In this review, we describe three senescence-inducing …
A new tumor suppressor pathway has begun to emerge quite recently, after the realization …

… of senescence are not limited to senescent tumor or stromal cells. Accumulating evidence
indicates that immune cell senescence contributes to suppression of anti-tumor immunity, thus …

… how the senescence response, initially a tumor suppressor … , cellular features and
consequences of senescence. We explore how the senescence response, initially a tumor …

… Cellular senescence can be triggered by a number of factors … mechanism of senescence
involves p16 and p53 tumor suppressor genes … The p16-mediated senescence acts through the …

… effects on cells that regulate cell proliferation and differentiation, enmeshing cancer onset
and progression with systemic aging and with cellular senescence and immortalization. The …

… The rapid advances in cellular senescence—a highly relevant phenotype in physiology and
disease widely involved in eukaryotic organism physiology—make it difficult to keep up with …

… of cellular senescence in tumor suppression. Here we discuss the molecular mechanisms
that direct cellular senescence and reveal its potential for tumor suppression. J. Med. …

… ‘replicative senescence’. Although it has been indicated that cellular senescence occurs in
… generally acts as a tumor suppressor, and senescence surveillance is thought to eliminate …