The endoplasmic reticulum: structure, function and response to cellular signaling

DS Schwarz, MD Blower - Cellular and molecular life sciences, 2016 - Springer
… of sheets to tubules occur in response to specific cellular signals. … cellular signals communicate
with ER shaping proteins to change the shape of the ER in response to cellular signals

The endoplasmic reticulum: a multifunctional signaling organelle

MJ Berridge - Cell calcium, 2002 - Elsevier
endoplasmic reticulum (ER) is a multifunctional signaling organelle that controls a wide range
of cellular … One of its primary functions is as a source of the Ca 2+ signals that are released …

Crosstalk of endoplasmic reticulum exit sites and cellular signaling

FG Centonze, H Farhan - FEBS letters, 2019 - Wiley Online Library
… In this review, we focus on signaling pathways that target components of the ER export … how
signaling generated at the ER regulates various homeostatic cellular processes such as cell

Calcium at the center of cell signaling: interplay between endoplasmic reticulum, mitochondria, and lysosomes

A Raffaello, C Mammucari, G Gherardi… - Trends in biochemical …, 2016 - cell.com
… for whole-cell Ca 2+ homeostasis. In particular, the structures of the endoplasmic reticulum
(ER) … , and the analysis of lysosomal Ca 2+ signaling are milestones on the route towards a …

Cellular mechanisms of endoplasmic reticulum stress signaling in health and disease. 1. An overview

E Dufey, D Sepúlveda… - … of Physiology-Cell …, 2014 - journals.physiology.org
signaling mechanism behind the UPR and provides a context to understanding the impact of
ER stress in human disease. We review mechanistic aspects of signal … to determine cell fate…

Cell signaling and stress responses

GS Hotamisligil, RJ Davis - Cold Spring Harbor …, 2016 - cshperspectives.cshlp.org
… The UPR is engaged within the endoplasmic reticulum (ER) during biosynthetic stress and
leads to a coordinated inhibition of general protein translation and specific up-regulation of …

Relevance of endoplasmic reticulum stress cell signaling in liver cold ischemia reperfusion injury

E Folch-Puy, A Panisello, J Oliva, A Lopez… - International journal of …, 2016 - mdpi.com
… some protective cell signaling pathways in cold preservation conditions that interfere with
UPR/ER function and ERS alterations. This includes protective cell signaling pathways such as …

Endoplasmic reticulum stress signaling in disease

SJ Marciniak, D Ron - Physiological reviews, 2006 - journals.physiology.org
… provided by a membranous network called the endoplasmic reticulum (ER). With evolution
… synthesized endoplasmic reticulum “client” proteins presents unique dangers to the cell and …

Signal transduction from the endoplasmic reticulum to the cell nucleus

HL Pahl - Physiological reviews, 1999 - journals.physiology.org
… The endoplasmic reticulum (ER) is one of the largest cell organelles, its membranes …
membranes in a cell. The ER lumen, the internal space, comprises over 10% of the cell volume. This …

[PDF][PDF] ER-to-plasma membrane tethering proteins regulate cell signaling and ER morphology

AG Manford, CJ Stefan, HL Yuan, JA MacGurn… - Developmental cell, 2012 - cell.com
… The endoplasmic reticulum (ER) is a vast membrane network of sheets and tubules with
essential roles in protein modification and secretion, lipid synthesis, and calcium signaling. To …