… as central mediators of AF in metabolically-stressed hearts [6,7,8]. For one, mitochondria
isolated from atrial … The ensuing mitochondrial dysfunction and DNA damage are central to the …

The pathophysiology of atrial fibrillation (AF) remains incompletely understood, despite its
prevalence and contributing role in stroke and heart failure. Whereas previous studies have …

… Atrial fibrillation (AF) represents the most frequent arrhythmia encountered in clinical …
atrial electrical and structural remodeling13 while inflammation seems to be a central mediator…

… Atrial fibrillation (AF) is the most common cardiac arrhythmia. … The infiltration of immune
cells and proteins that mediate the … Mediators of the inflammatory response can alter atrial …

… signalling pathways play a major, central role in regulating atrial fibrotic remodelling in AF.
The … CTGF as the central mediator of tissue remodelling and atrial fibrosis. ⟙ (red arrow) …

… a CARD and caspase 1 and plays a central role in innate immunity. NLRP3 inflammasomes
are also reported to be associated with atrial electrical remolding. Yao et al. reported that the …

… Atrial fibrillation (AF) is the most common cardiac arrhythmia with diverse pathophysiological
… Several molecular mediators are involved in the development of atrial fibrosis. Although a …

… In considering subcellular mediators linking structural changes in the atria and the
susceptibility for atrial fibrillation, AngII stands out as having a central role. AngII, generated either …

… Furthermore, various inflammatory markers and mediators such as C-reactive protein (CRP)…
Finally, recent studies indicate that activated inflammatory cells and inflammatory mediators …

… can be the key mediators of atrial fibrosis as well as structural remodeling [22, 24,25,26,27]. …
Adiponectin influences the functioning of the heart through central nervous system when …