Pathophysiology of hepatic encephalopathy: a new look at ammonia

RF Butterworth - Metabolic brain disease, 2002 - Springer
… utilization rates in patients with chronic liver failure. In addition to the … ammonia production,
new approaches to the treatment of hepatic encephalopathy by lowering of brain ammonia

Blood ammonia levels and hepatic encephalopathy

AH Lockwood - Metabolic brain disease, 2004 - Springer
… with increasing arterial ammonia levels. Encephalopathic participants in this study had
significantly higher brain ammonia metabolic rates than those without encephalopathy. This …

Ammonia: key factor in the pathogenesis of hepatic encephalopathy

RF Butterworth, JF Giguère, J Michaud, J Lavoie… - Neurochemical …, 1987 - Springer
hepatic coma resulting from fulminant hepatic failure, brain … dying in hepatic coma resulting
from chronic liver disease. In … cirrhotic patient dying in hepatic coma. The nuclei of affected …

The pathophysiologic basis of hepatic encephalopathy: central role for ammonia and inflammation

D Shawcross, R Jalan - Cellular and Molecular Life Sciences CMLS, 2005 - Springer
… concentrations of ammonia may increase the uptake of ammonia in the brain through an …
brain barrier to ammonia [19]. In experimental animals with acute liver failure, brain ammonia

Ammonia‐lowering strategies for the treatment of hepatic encephalopathy

CF Rose - Clinical Pharmacology & Therapeutics, 2012 - Wiley Online Library
… Hyperammonemia leads to neurotoxic levels of brain ammonia and is a major factor
involved in the pathogenesis of hepatic encephalopathy (HE). Ammonia-lowering treatments …

Hepatic encephalopathy

J Córdoba, B Mínguez - Seminars in liver disease, 2008 - thieme-connect.com
… plasma ammonia, measures to reduce brain edema, and liver-support devices. … Cerebral
ammonia metabolism in patients with severe liver disease and minimal hepatic encephalopathy

Pathogenesis of hepatic encephalopathy: role of ammonia and systemic inflammation

DR Aldridge, EJ Tranah, DL Shawcross - Journal of clinical and …, 2015 - Elsevier
… The syndrome we refer to as Hepatic Encephalopathy (HE) was first characterized by a …
away from the liver, induced elevated blood and brain ammonia concentrations in association …

Pathogenesis of Hepatic Encephalopathy-with Special Reference to the Roles of Ammonia

CO WALKER, S SCHENKER - The American journal of clinical nutrition, 1970 - Elsevier
… As regards ammonia, the only likely toxin meaningfully … brain, probably at the site of cerebral
ammonia detoxication, ie, at the α-ketoglutarate-glutamate-glutamine level. In acute coma, …

[HTML][HTML] Hepatic encephalopathy

RF Butterworth - Alcohol Research & Health, 2003 - ncbi.nlm.nih.gov
… One of the main causes of brain dysfunction in patients with hepatic encephalopathy (HE)
is the accumulation of ammonia in the blood, which the patient’s liver, damaged by alcoholic …

Ammonia and its role in the pathogenesis of hepatic encephalopathy

PJ Parekh, LA Balart - Clinics in liver disease, 2015 - liver.theclinics.com
ammonia levels adapt by increasing permeability surface area (PSA). Cerebral ammonia
The increased PSA allows ammonia to diffuse across the blood-brain barrier more freely …