What is normal in normal aging? Effects of aging, amyloid and Alzheimer's disease on the cerebral cortex and the hippocampus

…, Alzheimer's Disease Neuroimaging Initiative - Progress in …, 2014 - Elsevier
… of undetected disease. We review recent research on changes of the cerebral cortex and …
We argue that prominent cortical reductions are evident in fronto-temporal regions in elderly …

The topographical and neuroanatomical distribution of neurofibrillary tangles and neuritic plaques in the cerebral cortex of patients with Alzheimer's disease

SE Arnold, BT Hyman, J Flory, AR Damasio… - Cerebral …, 1991 - academic.oup.com
… As noted by Van Hoesen and Damasio (1987), the sheer size of the cerebral cortex, the …
Against this background we decided to concentrate on cerebral cortex and on NFTs and …

Cerebral cortex pathology in aging and Alzheimer's disease: a quantitative survey of large hospital-based geriatric and psychiatric cohorts

P Giannakopoulos, PR Hof, JP Michel, J Guimon… - Brain Research …, 1997 - Elsevier
… aging and Alzheimer's disease affect select cortical circuits … Alzheimer's disease. Despite
several lines of evidence involving amyloid deposit in the pathogenesis of Alzheimer's disease

Pathological features of cerebral cortical capillaries are doubled in Alzheimer's disease and Parkinson's disease

E Farkas, GI De Jong, RAI de Vos… - Acta …, 2000 - Springer
… Abstract Cerebral … of cerebral microvessels in Alzheimer’s disease (AD; n = 5) and Parkinson’s
diseasse (PD; n = 10). The capillary microanatomy in samples from the cingulate cortex

Alzheimer's disease: neurofibrillary tangles in nuclei that project to the cerebral cortex

DC German, CL White III, DR Sparkman - Neuroscience, 1987 - Elsevier
… that Alzheimer’s disease is a disease of the cerebral cortex … that the cerebral cortex is the
primary target of the disease and … due to retrograde transport of a cortical pathogen or failure of …

Preamyloid deposits in the cerebral cortex of patients with Alzheimer's disease and nondemented individuals

F Tagliavini, G Giaccone, B Frangione, O Bugiani - Neuroscience letters, 1988 - Elsevier
Alzheimer's disease [5, 17]. In congophilic angiopathy, amyloid accumulates in the wall of
leptomeningeal and cortical … raised that recognized cerebral amyloid in Alzheimer's disease [1, …

Special properties of cholinesterases in the cerebral cortex of Alzheimer's disease

C Geula, M Mesulam - Brain research, 1989 - Elsevier
… lary tangles in a characteristic density and distribution represents the diagnostic hallmark
of Alzheimer’s disease (AD)i2. Additional findings in the cerebral cortex include a loss of large …

The effects of aging and Alzheimer's disease on cerebral cortical anatomy: specificity and differential relationships with cognition

A Bakkour, JC Morris, DA Wolk, BC Dickerson - Neuroimage, 2013 - Elsevier
Although both normal aging and Alzheimer's disease (AD) are associated with regional cortical
atrophy, few studies have directly compared the spatial patterns and magnitude of effects …

Increased levels of DNA breaks in cerebral cortex of Alzheimer's disease patients

E Mullaart, METI Boerrigter, R Ravid, DF Swaab… - Neurobiology of …, 1990 - Elsevier
… It has been hypothesized that Alzheimer's disease (AD) is caused by an accumulation of …
breaks and alkali-labile sites in cerebral cortex tissue samples from AD patients and controls …

Mechanical property alterations across the cerebral cortex due to Alzheimer's disease

LV Hiscox, CL Johnson, MDJ McGarry… - Brain …, 2020 - academic.oup.com
… of the cerebral cortex in patients with Alzheimer’s disease (N = … in Alzheimer’s disease when
white matter, cortical grey matter … observed in white matter and cortical grey matter, but not in …