The cerebrospinal fluid (CSF) of multiple sclerosis (MS) patients is characterized by increased
concentrations of immunoglobulin (Ig), which on electrophoretic analysis shows restricted …

… antibodies, in cerebrospinal fluid samples of 16 patients. From the cerebrospinal fluid of two
… In striking contrast to IgM-chains from peripheral blood, IgM-chains from cerebrospinal fluid …

… Four of these unidentified variants occurred in the setting of either somatic hypermutation
in primary CNS lymphoma or APOBEC-associated mutation in breast cancer, suggestive of …

… In contrast to traditional analyses, which compare germline transcriptomes and proteomes,
our approach is based on the subject-specific somatic hypermutation and hypervariable V(D)…

… Aligned reads were used to determine specific immunoglobulin gene rearrangements and
unique sequences resulting from additional somatic hypermutation representing specific B-…

… in the cerebral meninges [13], [14], central nervous system and the cerebrospinal fluid of both
… chain genes in the peripheral blood and cerebral spinal fluid of the same MS patients were …

… Cerebrospinal fluid (CSF) is a clear and paucicellular fluid that circulates within the ventricular
system and the subarachnoid space of the central nervous system (CNS), and diverse …

… -cell clonal expansion and somatic hypermutation of Ig-… somatic hypermutation and B-cell
clonal expansion are characteristic of the adaptive immune response in the cerebrospinal fluid (…

… (Ig-VH) genes of B cells in the cerebrospinal fluid (CSF) of 10 patients with PTC. Using RT…
ies have shown somatic hypermutated clonal expansion of somatic hypermutated B cells in …

… , including 32 from a single patient with a hypermutated tumour. The average variant allele
fraction of … In our 30 CSF–tumour pairs without DNA hypermutation, the percentage of shared …