… although CFTR modulator therapies … therapies to be developed for all persons with cystic
fibrosis. The clinical efficacy of the current combination therapies for patients with cystic fibrosis …

… of cystic fibrosis (CF) by decreasing morbidities and increasing survival.CFTR modulator
therapies have been developed to increase or restore the function of the aberrant CFTR protein …

… In this review we outline how CFTR modulator drugs restore function to the CFTR protein
and the … We also describe the real-world impact of CFTR modulators on both pulmonary and …

… CFTR modulators has resulted in immediate questions about the new state of cystic fibrosis
… key questions about cystic fibrosis disease in the era of modulator therapy, highlighting state-…

… ultimate therapy call … CFTR modulator therapies in the referral and listing process. The
purpose of this review article, therefore, is threefold: first, to describe the effects of new therapies, …

… In the aforementioned clinical trials, CFTR modulators were … with real-world CFTR modulator
safety data have raised flags … -world AEs reported for CFTR modulator therapies, as well as …

… , consequences of therapy, and incompletely understood consequences of CFTR deficiency
(… potential effects of CFTR modulators on the different aspects of cystic fibrosis are described …

… characterises the DDIs seen between CFTR modulator therapies and other drugs used in
pwCF … –drug interactions (DDIs) of modulators and drugs commonly used in cystic fibrosis care …

… research (2019–2021) regarding CFTR modulators, including studies that demonstrate the
… FDA-approved modulator. Efforts to make effective CFTR modulators available to younger …

… CFTR modulator therapy can improve pulmonary abnormalities due to CF, such as …
cessation of therapy [15], indicating that CFTR modulator therapy is a chronic, lifelong treatment. …