Methodological advances in drug discovery for Chagas disease

JM Bustamante, RL Tarleton - Expert opinion on drug discovery, 2011 - Taylor & Francis
… review the development of Chagas disease drug discovery methodology, … advances
emphasize the potential for additional progress resulting in new treatments for Chagas disease in …

Retrospect, advances and challenges in Chagas disease diagnosis: a comprehensive review

AG Schijman, J Alonso-Padilla, C Britto… - The Lancet Regional …, 2024 - thelancet.com
… We explore recent developments in Chagas disease diagnosis, reviewing historical context
and advancements. Despite progress, challenges persist. This article contributes to the …

Advances and challenges towards a vaccine against Chagas disease

I Quijano-Hernandez, E Dumonteil - Human vaccines, 2011 - Taylor & Francis
… , ethical and logistical issues, advances in our understanding of Chagas disease pathogenesis
and in vaccine development against other diseases are providing some clues about how …

Challenges in Chagas disease drug development

AF Francisco, S Jayawardhana, F Olmo, MD Lewis… - Molecules, 2020 - mdpi.com
… Here, we will provide an overview of the current status of Chagas disease drug development,
highlight those areas where progress can be expected, and describe how fundamental …

Challenges in Chagas disease drug discovery: a review

R Paucar, E Moreno-Viguri… - Current Medicinal …, 2016 - ingentaconnect.com
… the treatment. Thus, there is an urgent need for new effective, safe and affordable drugs to
fight against this complex disease. … drugs for the treatment of Chagas disease during the last …

Navigating drug repurposing for Chagas disease: advances, challenges, and opportunities

EOJ Porta, K Kalesh, PG Steel - Frontiers in pharmacology, 2023 - frontiersin.org
treating Chagas disease. Organized by original therapeutic area, we describe significant
recent advances, … the development of new, safe, and effective treatments for Chagas disease. …

Preclinical advances and the immunophysiology of a new therapeutic Chagas disease vaccine

KM Jones, C Poveda, L Versteeg… - Expert review of …, 2022 - Taylor & Francis
… Currently, the treatment for Chagas disease is limited to two … patients who were treated after
cardiac disease was established … to slow disease progression and prevent death in Chagas

Chagas disease: changes in knowledge and management

FX Lescure, G Le Loup, H Freilij… - … infectious diseases, 2010 - thelancet.com
… of the pathophysiology, diagnosis, and treatment of Chagas disease in the past few years. …
the Brazilian scientist Carlos Chagas. In view of recent advances in prevention and control, …

Chagas disease

AS de Sousa, D Vermeij, AN Ramos, AO Luquetti - The Lancet, 2024 - thelancet.com
… Evidence is emerging that the diverse genetic makeup of the parasite is responsible for
distinct outcomes in diagnosis and treatment of Chagas disease, but this should be researched …

Current drug therapy and pharmaceutical challenges for Chagas disease

J Bermudez, C Davies, A Simonazzi, JP Real, S Palma - Acta tropica, 2016 - Elsevier
… of Chagas disease are limited to case detection and treatment, … will discuss the treatment of
human Chagas disease with the … trial and innovative strategies for treating Chagas disease. …