American trypanosomiasis, or Chagas disease, is the result of infection by the Trypanosoma
cruzi parasite. Endemic in Latin America where it is the major cause of death from …

… for drug discovery. Finally, we propose the use of artificial intelligence to accelerate drug
discovery in Chagas disease and … that need to be overcome in Chagas disease drug discovery. …

… Introduction: Chagas disease (CD) is a neglected disease caused by the protozoan parasite
… novel drug discovery, there has been no progress since the 1960s with the same two drugs, …

… new opportunities for drug discovery for Chagas disease. … In the last decade, discovery efforts
in Chagas disease have … of Chagas disease, have changed the drug discovery landscape. …

… CD drug discovery … disease from different points of view: eg, control of transmission, access
to diagnostics and treatment, patients care or the discovery and development of new drugs. …

… for Chagas disease … Chagas disease drug discovery. Advances in pre-clinical profiling
assays, the current compound landscape and progress towards the identification of new drug …

… is a major issue for further drug discovery efforts. Our goal was to identify cell-based
assays that could differentiate current nitro-aromatic drugs nifurtimox and benznidazole from …

… aspect of Chagas disease drug discovery: the … Chagas disease drug discovery programmes,
but we consider it to be a valuable component of the early assessment of promising drug …

… drug discovery for CD are discussed. It provides a personal viewpoint based on multiple
discussions and collaborations with scientists from the Chagas community around the globe. …

… In this review, we have discussed the different drug discovery approaches used for Chagas
disease, as well as some drug targets explored in the last few years. In this context, we have …