… that do not meet certain criteria, is a real need in Chagas disease drug discovery programs.
… a high content screening technology to assist the drug discovery and development process. …

… treatment of this disease, this review describes recent advances (2013–2019) concerning
nitroheterocyclic compounds … cruzi parasites, as well as new perspectives for future research. …

… old nitroheterocyclic drugs, benznidazole and nifurtimox, are currently available for the
treatment of Chagas disease … of screening cascades and the definition of compound progression …

… Introduction: Chagas disease (CD) is a neglected disease … In terms of novel drug discovery,
there has been no progress … of nitroheterocycles: benznidazole (BZN – Figure 1 , compound 1…

… Nitro heterocyclic compounds have served at the forefront of Chagas disease … further
research into these compounds. The renewed interest in this class against kinetoplastid parasite …

… between research institutions and pharmaceutical companies. … and recent advances in
Chagas disease drug discovery. … The drugs available are limited to two old nitroheterocyclic …

… Currently only two nitroheterocyclic compounds are available to treat Chagas … The drug
discovery process for Chagas disease has been ongoing with thousands of compounds tested …

… only approved therapeutics for the treatment of Chagas disease are two nitroheterocyclic …
in drug discovery for Chagas disease, including methodology, in vitro screening studies …

… compounds forward for the treatment of this disease. New developments in the Chagas
field, … options for CD are limited to only two old nitro-heterocyclic drugs: benznidazole (Rochagan/…

… old nitroheterocyclic drugs with serious side effects. The need for new and safer drugs has
prompted numerous drug discovery … medicinal chemistry programs in Chagas drug discovery. …