… The goal of checkpoint inhibitor combination therapy is to improve clinical response and …
, evidence and challenges in designing synergistic combinations with checkpoint inhibitors. …

… In this review, we discuss current challenges and new potential approaches to implement
rationally designed clinical trials of IO drugs, particularly those targeting immune checkpoints. …

… In the context of a rapid expansion of immunooncology, this review aims to outline the
challenges and opportunities that accompany the clinical development of immunotherapy in HCC. …

… the clinical breakthrough of checkpoint inhibitors (CPIs) targeting … mainly on the opportunities
and challenges of current CPIs in … This study combining immune checkpoint inhibition with …

… the challenges leading to the lack of efficacy with ICI use and discuss potential strategies to
overcome those challenges … We also discuss the challenges associated with ICI therapy in …

… Immune checkpoint inhibitors have transformed cancer therapy, but their optimal use is still
… on our research in therapeutic biomarkers and toxicities from immune checkpoint inhibitors. …

… checkpoint inhibitors is a significant challenge. In this review, we focus on the current research
progress of immune checkpoint inhibitors … resistance to immune checkpoint inhibitors and …

… immunologic effects of checkpoint blockade, delineate mechanisms of resistance to these
therapies and identify optimal combination of agonistic signaling, checkpoint inhibitors as well …

… In these patients, immune-checkpoint inhibitors (ICIs) can provide durable responses and
… Unresolved challenges for the optimal use of ICIs with curative intent include concerns …

… on immune checkpoint inhibitor antibodies − their principle mechanism of actions, pathways
targeted successfully and potential opportunities, as well as clinical challenges stemming …