Genome editing for crop improvement: challenges and opportunities

NA Abdallah, CS Prakash, AG McHughen - GM Crops & Food, 2015 - Taylor & Francis
Genome or gene editing includes several new techniques to help scientists precisely
modify genome sequences. The techniques also enables us to alter the regulation of …

Detection and identification of genome editing in plants: challenges and opportunities

L Grohmann, J Keilwagen, N Duensing… - Frontiers in Plant …, 2019 - frontiersin.org
… New breeding techniques such as genome editing diversify … thereof is demanded, a new
challenge will arise for (official) … ie, an organism produced by genome editing carrying a specific …

The promise and challenge of therapeutic genome editing

JA Doudna - Nature, 2020 - nature.com
… In this Review, I discuss the therapeutic opportunities of genome editing, the ability to alter …
genome editing in the real world. A comparison of somatic-cell and germline editing highlights …

Genome editing in cotton: challenges and opportunities

Z Khan, SH Khan, A Ahmed, MU Iqbal… - Journal of Cotton …, 2023 - Springer
… In this review, a general description of the available genome editing platforms has been
given with special emphasis on using these platforms for genetic improvement in cotton. …

[HTML][HTML] Genome editing in cancer: Challenges and potential opportunities

D Breier, D Peer - Bioactive Materials, 2023 - Elsevier
… still many remaining challenges before genome editing can be used in the clinic as a therapy
for cancer, there are currently many possible ways to overcome those challenges that are …

Advancing genome editing with artificial intelligence: opportunities, challenges, and future directions

S Dixit, A Kumar, K Srinivasan… - … in Bioengineering and …, 2024 - frontiersin.org
… , suitable delivery methods for CRISPR cargoes, improving editing efficiency, and ensuring
… CRISPR-based genome editing technologies and addresses existing challenges. It also …

Therapeutic genome editing: prospects and challenges

DBT Cox, RJ Platt, F Zhang - Nature medicine, 2015 - nature.com
… the different nuclease-based genome editing technologies, the mechanisms … challenges
that will need to be addressed to realize their clinical translation. Although many genome editing

CRISPR/Cas9-based genome editing for disease modeling and therapy: challenges and opportunities for nonviral delivery

HX Wang, M Li, CM Lee, S Chakraborty… - Chemical …, 2017 - ACS Publications
… the genome editing elements in the form of DNA, mRNA, or protein, and the opportunities of
… We highlight the lessons learned from nonviral gene delivery in the past three decades and …

Genome editing of the blood: opportunities and challenges

MH Porteus - Current stem cell reports, 2015 - Springer
… The progress and challenges of genome editing of blood are discussed. … This review
will focus on genome editing using engineered nucleases for genome editing (Fig. 1). …

Non-viral delivery systems for CRISPR/Cas9-based genome editing: Challenges and opportunities

L Li, S Hu, X Chen - Biomaterials, 2018 - Elsevier
… Instead, we will discuss the limitations and challenges in CRISPR/Cas9-based genome editing,
focus … these obstacles to fulfill the clinical need of CRISPR/Cas9-based genome editing. …