… an excellent treatment target. A large number of molecular pathways involved in renal fibrosis
… We discuss the potential reasons for the poor translation in treatment of renal fibrosis and …

… In a simplistic view, renal fibrosis represents a failed wound-… Among the many fibrogenic
factors that regulate renal fibrotic … leading to renal fibrosis, and discusses the challenges and …

… Renal fibrosis is the principal process underlying … renal disease (ESRD). It is a relatively
uniform response involving glomerulosclerosis, tubulointerstitial fibrosis and changes in renal …

… to renal fibrosis, which is also tightly regulated by TGF-β. However, anti-TGF-β treatment for
renal fibrosis … into mechanisms and treatment of renal fibrosis remains highly challenging. …

… Given the growing evidence for EV-mediated renal diseases, … from stem cells in renal
diseases will be outlined. Finally, we … the challenges of EVs-based therapies for renal diseases. …

… renal fibrosis. The possible mechanisms, biomarkers, and strategies for prevention and
treatment of renal fibrosis … a comprehensive understanding of the renal fibrosis. Finally, we would …

… The search for therapeutic targets of renal … renal fibrosis by blocking TGF-β signaling has
been unsuccessful, but the investigation of signaling pathways involved in late stages of fibrosis …

… as antifibrotic therapy stalled due to technical challenges in manufacturing bioactive BMP-7 …
in murine models of renal fibrosis 85 and a structural analogue is in phase II clinical testing. …

… Of six cases whose pre-treatment renal function was noted, only one showed renal … Of six
cases whose pre-treatment renal function was noted, only one showed renal insufficiency with …

… promising agents to treat renal fibrosis. ET-1 is a major peptide involved in renal fibrosis
mainly through the … One of the main challenges in CKD remains the direct assessment of renal …