… , presents identification of non-genotoxic carcinogens with a different set of challenges.
Today, human non-genotoxic cancer risk assessment is done on a case-by-case basis using a …

… and cancer risk assessment if a human metabolite of genotoxic concern is identified during
the course of drug development. Since such challenges … a carcinogenic risk assessment for …

… Assessment of genotoxic and carcinogenic potential is … of genetic damage and cancer. Using
genotoxicity assays to predict … The development of such an IATA is a challenging task and …

… cals to be similar makes it difficult to assess by statistical means which measure might be
most pertinent to a mechanism of activity. Hence, the challenge to the user is to determine if it …

… chemicals for risk assessment. Furthermore, we propose that … We propose that these
challenges highlight the need for … We contend that inclusion of a carcinogenic chemical(s) will …

… of administration of the carcinogen, it became apparent that … , mechanistic approach to cancer
risk assessment based on a … goal is an assessment of possible carcinogenic risk in humans…

… when conducting assessments of cancer risk to humans. Also, the risk assessment approach
… of permissible exposure levels at which no relevant human cancer risks are anticipated. …

… The current practice in carcinogen risk assessment of using a linearized multistage model
and assuming lowdose linearity is based on several false premises. In many cases linearity at …

… sponsored by the National Cancer Institute/National … -1 and PTE-2 prediction challenges,
we make the final point … concern for risk assessment, ie human carcinogenicity. Experiments …

… which carcinogen exposure can be assessed. Recently, epigenetic events have emerged
as key mechanisms in cancer … and challenges in incorporating epigenetics into carcinogen …