… available rodent carcinogenicity database. The database on non-cancer endpoints was …
The existing cancer TTC database needs to be assessed, using a standardised method for …

… challenges. These approaches include focusing on real-world exposures and advancing our
methods to address challenges in cancer hazard assessments … carcinogenicity assessment …

… that contributes to the carcinogenic process. … to the carcinogenic process. Therefore, besides
genotoxicity testing, mechanistic studies are also needed to clarify the MoA of carcinogenic …

… While NAT2 is involved in detoxification of aromatic amine bladder carcinogens, it apparently
plays an opposite role in colon cancer through the metabolic activation of the carcinogenic …

… rodent cancer bioassays (ie, the “Rethinking Carcinogenicity … Several challenges are yet to
be met when assessing the … opportunity to add to carcinogenicity assessment both in a role as …

… These key events, in turn, will enhance analysis for defining MOAs to better assess human
carcinogenic potential/risk. Specifically, these endpoints include increases in cell proliferation …

… , the paradigm for carcinogenicity assessment has depended … model to support cancer risk
assessment of pharmaceuticals. … Our fear of cancer has resulted in a conservatism that has …

… This situation might be frequent in carcinogen-induced tumors carrying high mutational …
main challenge in the field of cancer immunotherapy currently. Expression of PD-L1 assessed by …

… Cancer risk assessment is a major part of establishing the … Because the nonclinical
carcinogenicity assessment program is … results can be challenging. The interim incidence profile, …

… The focus of this review is on the cancer risk to workers exposed to airborne CNT or CNF
during the production and use of these materials. The findings of this review, in general, affirm …