… Our evaluation challenges a number of key elements of the … carcinogenic potency data (TD
50 s in mg/kg/day, the cancer … subcutaneous injection with assessment of tumor development …

… This survey summarizes legal, regulatory, scientific and technical challenges that have to
be met to facilitate the regulatory use of ‘omics technologies. Thereby, it serves as background …

… cancer effect, cancer slope factors (CSF) – usually a 95% upper confidence limit – are used
to estimate the risk of cancer associated with exposure to a carcinogenic … and challenges …

… As noted previously, NIOSH assumes TiO 2 to be carcinogenic in rats following a non-…
cancer. On that basis, NIOSH will not exclude that nano/ultrafine-TiO 2 is a human carcinogen and …

… cancer risk assessments supports, rather than undermines, public health by focusing attention
where it belongs, on substances that are most likely to pose a carcinogenic … challenges for …

… of a compound has become a de facto surrogate for carcinogenicity (Fig. 1). A detailed …
term “neo-genotoxins,” presents both new challenges and new opportunities for the field. A …

… Recent progress in developing advanced cell and gene therapy products is generating
new challenges for cancer risk assessment. Whilst existing genetic toxicity testing paradigms …

… assessment conducted within the European Union (EU) renewal process, and explains the
differences in the carcinogenicity assessment … between exposure and cancer incidences are …

… the challenges of … carcinogenic activity of many nongenotoxic agents can have species,
strain and tissue specificity, and their relevance to human cancer risk needs to be assessed …

… on Cancer (IARC) are a prominent example of such an expert review process. The goal of
the Monograph Programme is to assess carcinogenic … poses special challenges to scientific …