… 3h whereas in the polyamine-depleted cells it remained constant up … To confirm further the
effect of polyamine depletion on … Polyamine depletion by treatment with DFMO decreased the …

… This analysis revealed changes in the expression of 483 genes that were arranged in six
clusters (Fig. 3 and supplemental Table 3). Three clusters (1, 4, and 5) contained genes whose …

… Cells released from the polyamine inhibition lost the ability to … this study indicate that polyamine
pool depletion achieved by … p21-mediated changes in gene expression, development of …

… The changes in c-myc during polyamine depletion in COLO 320 cells did not appear to
result simply from a generalized decrease in gene expression (Fig. 3, A and B). Steady-state …

… the hypothesis that polyamine depletion results in growth inhibition by altering expression of
the TGF-… The change in activation of protooncogene expression plays a minor role in growth …

… increases in p53 mRNA stability and the resultant protein synthesis in DFMO-treated cells
are completely prevented by the addition of exogenous spermidine, these observed changes …

… , and polyamine depletion can cause DNA structure to change. So polyamines might not
be … Thus polyamines are of great significance to maintain the structural balance of DNA and …

… To determine whether the induction of TGF-βRI expression by polyamine depletion is cell-type
dependent, we examined changes in levels of TGF-βRI and TGF-βRII mRNAs and …

… Initial analysis of the data focused on changes in the expression of polyamine metabolism
genes in order to validate the … by nutritional depletion rather than by using chemical inhibitors. …

… of accumulation and depletion of polyamines occur during cell-… of polyamine metabolism
undergo co-ordinate changes during cell… of expression leads to cyclical phases of depletion and …