… ion channel TRPM2 is highly expressed in a number of cancers. In neuroblastoma, full-length
TRPM2 (TRPM2-L) … Cells expressing the dominant negative short isoform (TRPM2-S) had …

… to TRPM2 alternative spliced isoforms is largely unavailable (24). Several splice variants of
TRPM2 … receptor activation can induce TRPM2 channel activation. This finding implies that …

… In summary, we identified a fundamental relationship between oxidant-activated TRPM2
channel and its associated short splice variant TRPM2-S in the gating of large Ca 2+ influx and …

… splice variants may play a role modulating the function, ion selectivity and localization of
these channels. … In this review we focus on the TRPM2 channel and discuss its molecular and …

… In addition to the full-length TRPM2 (TRPM2-L), physiological TRPM2 splice variants missing
one or both exons 11 and 27 (Fig. 1) have been identified in human hematopoietic cells (…

… 2 (TRPM2) protein forms a Ca 2+ -permeable cationic channel … functional properties of the
TRPM2 channel, and particularly … A splice variant reveals a mode of activation independent of …

… TRPM2 is a Ca 2+ -permeable channel that is activated by oxidative stress and confers
susceptibility to cell death. Here, an isoform of TRPM2 was … This splice variant was found in other …

… The generation of N-terminal truncated TRPM2 channels equivalent to the splice variant
TRPM2-ΔN [10] was performed by the introduction of pairs of Afl II recognition sites into the …

… and FRET/FLIM assays revealed the interaction of TRPM2 and CD38 and we propose a
transport‐related nucleotide export via CD38 as a novel mechanism of TRPM2 activation. …

… the channel selectivity, localization and function [4]. This review focuses on the molecular and
channel properties of TRPM2, … splicing variants of TRPM2 are TRPM2-ΔC and TRPM2-ΔN. …