… function as an adaptor of checkpoint initiation by localizing additional substrates for transducer
kinase phosphorylation and by perhaps linking checkpoint arrest to DNA damage repair. …

… These targeted effects result in cell cycle arrest of the tumor cells that … Cells whose cell cycle
is arrested, as also occurs in … Besides the targeted effects of ionizing radiation (X-ray) used …

… A model of ASRs to low dose ionizing radiation in confluence- and low serum-arrested human
… ‘A’ represents the adaptive checkpoint as discussed in the text. In contrast. only cyclin A …

… in cell cycle checkpoint arrest between HCTI 16 and HCTI 16 3-6 cells after IR (Fig. 3A).
HCTI 16 3-6 cells demonstrated extensive G2-M cell cycle checkpoint arrest after 5 Gy, with cell …

… -independent apoptosis in response to ionizing radiation. These authors and … checkpoint
signaling pathway and cell cycle arrest in human ES cells after exposure to 2 Gy of γ-radiation. …

… We show that, following a sustained G 2 checkpoint arrest, U-2-OS cells adapt and divide
with signs of unrepaired DNA breaks through a process regulated by the Plk1 and Chk1 …

… not affect radiation sensitivity of the cell, the G 2 /M checkpoint of the cell, or double-strand
break repair. Because ionizing radiation leads to a different cell cycle arrest (G 2 /M arrest) …

… ionizing radiation exposure is composed of two distinct types of biochemical pathways, that
is, the DNA damage cell cycle checkpoint … deployed by checkpoints for arresting the cell cycle …

… a G 1 arrest can be restored by ectopic expression of Chk2 and that the restoration of a G 1
arrest protects cells from apoptosis. We argue that natural absence of a G 1 checkpoint in ES …

… Caffeine even induced hyperphosphorylation of CHEK2 at times when the checkpoint was
… to further delineate the checkpoint pathways responsible for the late G2 arrest. IR induced …