… Checkpoint inhibitor-based immunotherapies that target … demonstrating that immune checkpoint
inhibitor efficacy is affected … to optimize the implementation of precision immunotherapy. …

… of checkpoint inhibitors. … to checkpoint inhibitor monotherapy. In our discussion we will
highlight the key paradigms being explored for future immunotherapy, with checkpoint inhibitors …

… immunotherapy is the durability of the responses that can be translated into survival benefit.
Indeed, in approved indications, checkpoint inhibitor immunotherapy … to these inhibitors. The …

… Inhibitory checkpoint pathways limit the threshold for T cell activation and duration of …
inhibitory checkpoints to evade immune eradication. Blockade of the T cell checkpoint inhibitors …

… Immune checkpoint inhibition is a well-established part of … 4 (CTLA-4) immune checkpoints
led to a series of clinical trials that … strategies of immune checkpoint inhibition plus agents that …

… of checkpoint inhibitor-based immunotherapy has ushered in … respond to current checkpoint
immunotherapies, avoidance … aids to checkpoint inhibitor immunotherapy in cancer (table). …

… Immune checkpoint inhibitors (ICIs) are monoclonal antibodies that block inhibitors of T-cell
activation and function. The use of ICIs can have beneficial effects on more than 14 different …

… of combined immunotherapy checkpoint inhibitors PD-1 and TIM-3 along with focal radiation
on murine gliomas resulted in improved survival versus anti-TIM-3 immunotherapy alone. In …

… them insensitive to checkpoint inhibitor immunotherapy [11]. Luckily, these extreme situations
are rather unique, and generally the expression of immune checkpoint genes is relatively …

… results suggest that combination immunotherapies offer even more … checkpoint inhibitors
and discusses the scientific overview of cancer immunotherapy, mechanisms of the inhibitors, …