… T cell checkpoint inhibitors … checkpoints in controlling the immunosuppressive tumor
microenvironment, and developing strategies to target these checkpoints for cancer immunotherapy. …

… results suggest that combination immunotherapies offer even more … checkpoint inhibitors
and discusses the scientific overview of cancer immunotherapy, mechanisms of the inhibitors, …

… discussion of different forms of immunotherapy agents other than checkpoint-modifying drugs.
… will continue to develop and possibly join the immunotherapeutic arsenal in a near future. …

… across inhibitory immune checkpoint receptors that are of great importance in resistance
to cancer immunotherapy. We will summarize the biology of different checkpoint molecules, …

… The discovery of immune checkpoint proteins such as PD-1/PDL-1 and CTLA-… cancer
immunotherapy. Therefore, humanized monoclonal antibodies, targeting these immune checkpoint …

… New-generation combinatorial therapies may overcome resistance mechanisms to immune
checkpoint therapy. In 2013, Science named cancer immunotherapy its Breakthrough of the …

… mechanisms of action of inhibitors of various immune checkpoints, it is crucial … -checkpoint
receptors that have been most actively studied in the context of clinical cancer immunotherapy…

… checkpoint inhibition has proven efficient in melanoma, non-small-cell lung cancer and renal
cancer… malignancies could benefit from new immunotherapy protocols and algorithms that …

… The rapidly growing field of cancer immunotherapy has developed largely as result of our
increased understanding of the immune system and malignancy [1–2] . One of the early …

… the immune checkpoint inhibitors, a novel class of immunotherapy first approved … checkpoint
inhibitors approved by the US Food and Drug Administration—ipilimumab, pembrolizumab, …