Regulatory assessment and risk management of chemical mixtures: challenges and ways forward

SK Bopp, A Kienzler, AN Richarz… - Critical Reviews in …, 2019 - Taylor & Francis
… developments, challenges, and possible ways forward not only in mixture risk assessment
(… management of mixtures. Risk assessment of combined exposures to multiple chemicals is …

Public health challenges posed by chemical mixtures.

H Hansen, CT De Rosa, H Pohl, M Fay… - Environmental Health …, 1998 - ehp.niehs.nih.gov
chemical mixtures of actual public health concern has been linked to the concept of completed
exposure pathways (… to pursue various aspects of chemical mixtures research such as to …

[HTML][HTML] Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

E Drakvik, R Altenburger, Y Aoki, T Backhaus… - Environment …, 2020 - Elsevier
… assessment and governance of chemical mixtures as well as to … ways forward for advancing
progress in the chemical mixture … scientific challenges for addressing chemical mixture risks …

Toxicology of chemical mixtures: challenges for today and the future

VJ Feron, JP Groten, D Jonker, FR Cassee… - Toxicology, 1995 - Elsevier
… conducted to illustrate the unjustifiableness of applying the additivity rule in a general way,
(b) describes studies in rats with mixtures of similarly acting nephrotoxicants and with nasal …

[HTML][HTML] New challenges in environmental analytical chemistry: identification of toxic compounds in complex mixtures

MH Dévier, P Mazellier, S Aït-Aïssa… - Comptes Rendus Chimie, 2011 - Elsevier
mixtures of known and unknown pollutants. One of the key challenges in environmental
chemistry … difficulty of evaluating various chemical classes and biological effects within complex …

Toxicology of chemical mixtures: a challenging quest along empirical sciences

JP Groten, WHM Heijne, RH Stierum, AP Freidig… - Environmental …, 2004 - Elsevier
… An easy way to study the toxic effects of a mixture in an empirical way is to compare its
effects with those of all constituents at comparable levels and duration of exposure at only one …

[HTML][HTML] Options for an environmental risk assessment of intentional and unintentional chemical mixtures under REACH: the status and ways forward

E Hassold, W Galert, J Schulze - Environmental Sciences Europe, 2021 - Springer
… assessment that is needed for a critical analysis of the available options and challenges to
address intentional and unintentional mixtures within REACH. The present paper has a clear …

Toxicological evaluation of chemical mixtures

VJ Feron, JP Groten - Food and chemical toxicology, 2002 - Elsevier
… Determining human health risks from exposure to chemical mixtures is a daunting challenge
… All chemicals in the mixture act in the same way, by the same mechanism, and differ only in …

Combined exposure to mixture of chemicals. An impossible challenge

B Pierre-Marie, D François, A Olivier… - … —the impacts of …, 2011 - books.google.com
… These properties have been used to define different ways of assessing mixture toxicity.
Revisiting the concepts from Plackett & Hewlett, Ashford (1981) has distinguished six possible …

Challenges in regulating pesticide mixtures

M Lydy, J Belden, C Wheelock, B Hammock… - Ecology and society, 2004 - JSTOR
… most feasible way to assign priorities to pesticide mixtures. … of the mechanisms of chemical
mixtures results in poor … compounds as well as chemical mixtures and their effects on …