Review of the toxicity of chemical mixtures: theory, policy, and regulatory practice

LS McCarty, CJ Borgert - Regulatory Toxicology and Pharmacology, 2006 - Elsevier
… views of and approaches to mixture toxicity, including identification … mixture toxicology, and
a review of how mixture toxicity theory and data are employed in current mixture regulations

Chemical mixtures: considering the evolution of toxicology and chemical assessment

E Monosson - Environmental health perspectives, 2005 - ehp.niehs.nih.gov
… Perhaps regulatory practices in the future may consider such studies. Another approach
that integrates the effects of chemical mixtures is biomonitoring. For example, employees …

Regulatory assessment and risk management of chemical mixtures: challenges and ways forward

SK Bopp, A Kienzler, AN Richarz… - Critical Reviews in …, 2019 - Taylor & Francis
… that drive the mixture risk. As chemicals with different applications and regulated separately
… toxicological effects, it is important to consider chemical mixtures across legislative sectors. …

[HTML][HTML] Statement on advancing the assessment of chemical mixtures and their risks for human health and the environment

E Drakvik, R Altenburger, Y Aoki, T Backhaus… - Environment …, 2020 - Elsevier
Regulatory initiatives should be launched to … regulatory frameworks to include prospective
mixture risk assessment and consider combined exposures to (real-life) chemical mixtures to …

[HTML][HTML] Regulatory assessment of chemical mixtures: requirements, current approaches and future perspectives

A Kienzler, SK Bopp, S van der Linden… - Regulatory Toxicology …, 2016 - Elsevier
… overview of the current regulatory requirements for chemical mixture assessment, with …
mixtures. Recent case studies, specifically focusing on mixture RA beyond the current regulatory

[PDF][PDF] Assessment of mixtures-review of regulatory requirements and guidance

A Kienzler, E Berggren, J Bessems… - JRC Science for …, 2014 - researchgate.net
… testing), especially in the case of the registration of chemical mixtures under sectorial
regulations such as the plant protection products and biocidal products regulations. However, for …

[HTML][HTML] Should the scope of human mixture risk assessment span legislative/regulatory silos for chemicals?

RM Evans, OV Martin, M Faust… - Science of the Total …, 2016 - Elsevier
mixture effects have been shown for chemicals regulated in different silos and 2) evidence
that humans are co-exposed to chemicals … why chemicals allocated to specific regulatory silos …

Public health guidance values for chemical mixtures: current practice and future directions

HR Pohl, H Hansen, CHSJ Chou - Regulatory toxicology and …, 1997 - Elsevier
… the mixture components may alter the toxicity and carcinogenicity through mechanisms such
CHEMICAL MIXTURES… Such interactions are postulated to result from chemically mediated …

Exposure to mixtures of chemical substances: is there a need for regulations?

JA Van Zorge - Food and Chemical Toxicology, 1996 - Elsevier
… exposure to chemical substances may … practice, exposure to individual chemicals has
usually been reduced to acceptable levels. The key question is whether exposure to mixtures at …

[HTML][HTML] … for international harmonisation, implementation and further development of suitable scientific approaches regarding the assessment of mixture effects

BC Fischer, S Rotter, J Schubert… - Food and Chemical …, 2020 - Elsevier
mixtures of chemicals have been proposed, but none has been widely implemented in
regulatory … harmonised approaches for risk assessment of chemical mixtures. Based on in vitro …