… The use of natural products as chemical scaffolds or starting materials to obtain novel compounds
… cruzi. We highlight the chemical modifications that might influence their bioactivity and …

… three major pathogen species (Trypanosoma brucei, Trypanosoma cruzi and Leishmania
infantum)… Several novel chemical scaffolds were identified as low μM and selective tri-tryp TryS …

… or Chagas disease is a prevalent, neglected and serious debilitating illness caused by the
kinetoplastid protozoan parasite Trypanosoma cruzi. The current chemotherapy is limited only …

… chemical entities based on coumarin and chalcone scaffolds, … stages of the Trypanosoma
cruzi parasite. Cytotoxicity assays … 2 and 5 in the designed scaffold seemed to be a key feature …

… the development of new chemical entities with potent activity against Trypanosoma cruzi, are
a … This new scaffold will be targeted to optimize in order to enhance its biological activity to …

… cruzi trans-sialidase (TcTS). However, inhibitors found to date are not strong enough to serve
as a lead scaffold… These compounds may serve as potent lead chemotherapeutic scaffolds …

Background: Chagas disease is a potentially life-threatening illness caused by the protozoan
parasite Trypanosoma cruzi and is transmitted to humans through the excreta of infected …

… of a specific SAR using high speed chemistry, three-dimensional enzyme structure guided
… to lengthen the diversity of chemical scaffolds available for developing cruzipain inhibitors. …

… Our results have shown that the isoxazolyl-sulfonamide scaffold is promising regarding
all biological activities studied herein, especially the inhibitory activity against T. cruzi. …

… Ultrastructural alterations after treatment of cardiomyocytes or macrophages infected by
Trypanosoma cruzi with the IC 50 value of HAD1 revealed alterations to amastigotes, showing …