… cruzi activity for compounds (3a-m, 4a-m), which possess different substituents in phenyl
ring in the scaffold shown in Scheme 2, allowed to establish structure-activity relationships (SAR…

… in the scientific knowledge of Trypanosoma cruzi in the period … scaffold identified in a
target-based screening was explored … This scaffold advanced by medicinal chemistry yielding oral …

… Trypanosoma cruzi worldwide, whereas an estimated 1000 global cases of African human
trypanosomiasis … compounds that belong to the flavonoid family and are chemically obtained …

… To further investigate the structure-activity-relationships of this scaffold, the … Chemicals and
reagents were obtained from commercial … Chemical shifts are reported in ppm with the natural …

… CD is caused by Trypanosoma cruzi (T. … or similar chemical scaffolds, while natural
product-based TRIs and compounds with large chemical diversity will be reported separately. …

… cruzi. This “neglected” purine scaffold was in general devoid of cytotoxicity and halogen or
small… substituents in the 3-position conferred the highest in vitro activity against intracellular T. …

… Thus, the exploration of innovative scaffolds, ideally with distinct mechanisms of action, is …
, and demonstration of their activity against Trypanosoma cruzi cells. Two demonstrated high …

… lead optimization programs, very few new chemical entities have moved forward to clinical …
and chemical scaffolds in various stages of development as potential new chemical entities to …

… kinetoplastid protozoan parasite Trypanosoma cruzi. Despite … chemical features to allow the
identification of new scaffolds … In order to confirm the activity of the scaffold found we carried …

… with antiproliferative Trypanosoma cruzi properties was … These compounds inhibit the growth
of Trypanosoma cruzi, … of CL clone B5 of Trypanosoma cruzi. To verify selectivity towards …