[HTML][HTML] Carcinogenicity assessment: Addressing the challenges of cancer and chemicals in the environment

F Madia, A Worth, M Whelan, R Corvi - Environment international, 2019 - Elsevier
chemical safety assessment has to inform risk management measures and reduce the burden
of cancer, we reflect here on the role of carcinogenicity assessment … of chemical exposure …

Integration of data across toxicity endpoints for improved safety assessment of chemicals: the example of carcinogenicity assessment

F Madia, G Pillo, A Worth, R Corvi, P Prieto - Archives of Toxicology, 2021 - Springer
… In view of the need to enhance the assessment of consumer products called for in the EU
Chemicals … Here, we present the application of our methodology to carcinogenicity assessment, …

Current status of short-term tests for evaluation of genotoxicity, mutagenicity, and carcinogenicity of environmental chemicals and NCEs

M Bajpayee, AK Pandey, D Parmar… - Toxicology Mechanisms …, 2005 - Taylor & Francis
… , or carcinogenicity. Exposure to such compounds produces chemical changes in DNA, …
Hence, adequate tests on NCEs have to be undertaken for the risk assessment and hazard …

Predicting the carcinogenicity of chemicals with alternative approaches: recent advances

R Benigni - Expert Opinion on Drug Metabolism & Toxicology, 2014 - Taylor & Francis
… experiments when screening for the carcinogenic potential of chemicals. More recently,
EURL … , justify broader use of these methods to assess carcinogenic potential of chemicals. …

[HTML][HTML] Moving forward in carcinogenicity assessment: Report of an EURL ECVAM/ESTIV workshop

R Corvi, F Madia, KZ Guyton, P Kasper, R Rudel… - Toxicology in Vitro, 2017 - Elsevier
… The in vitro/in vivo test battery for assessing genotoxicity and chemical carcinogenicity
has been used for four decades now. Its practical usefulness for regulatory toxicology has …

Assessing chemical carcinogenicity: hazard identification, classification, and risk assessment. Insight from a toxicology forum state-of-the-science workshop

SP Felter, VS Bhat, PA Botham… - Critical Reviews in …, 2021 - Taylor & Francis
… approaches for assessing chemical carcinogenicity but … chemical carcinogenicity assessment
and support the establishment of a comprehensive decision tree to guide the assessment

In silico methods for carcinogenicity assessment

A Golbamaki, E Benfenati - In silico Methods for predicting drug toxicity, 2016 - Springer
… , time, and cost in the process of assessment of carcinogenicity of chemicals had lead to an
increased use of in silico methods as toxicological risk assessment tools. Among the in silico …

Environmental and chemical carcinogenesis

GN Wogan, SS Hecht, JS Felton, AH Conney… - Seminars in cancer …, 2004 - Elsevier
carcinogenic risk assessments based on examination by experts of all relevant information
to assess … of a widely disseminated environmental chemical carcinogen as a determinant of …

The impact of toxicity on carcinogenicity studies: implications for risk assessment

DG Hoel, JK Haseman, MD Hogan, J Huff… - …, 1988 - academic.oup.com
… If we reduce the 11 chemicals which are both carcinogenic and toxic to the seven for
which the toxicity could not be explained, then we see that three of them (1,4-dichlorobenzene, …

Evaluation of the carcinogenicity of chemicals: a review of the Monograph Program of the International Agency for Research on Cancer (1971 to 1977)

L Tomatis, C Agthe, H Bartsch, J Huff, R Montesano… - Cancer Research, 1978 - AACR
… absence of a carcinogenic effect in experimental animals or humans. The criteria on which
the carcino genicity of chemicals to humans and/or experimental animals was assessed, from …