Nanocarrier mediated delivery of siRNA/miRNA in combination with chemotherapeutic agents for cancer therapy: current progress and advances

NS Gandhi, RK Tekade, MB Chougule - Journal of Controlled Release, 2014 - Elsevier
… adopted for the delivery of siRNA/miRNA combinations with other anticancer agents (…
with siRNA or miRNA significantly enhances the sensitivity of chemotherapeutic drugs by …

[HTML][HTML] The novel strategies for next-generation cancer treatment: miRNA combined with chemotherapeutic agents for the treatment of cancer

C Chakraborty, AR Sharma, G Sharma, BK Sarkar… - Oncotarget, 2018 - ncbi.nlm.nih.gov
… In this post-genomic era, microRNAs (miRNAs) are receiving … of miRNAs and chemotherapeutic
agents for cancer treatment. Moreover, we attempted to portray the role of miRNAs in …

Nanoparticle-mediated co-delivery of chemotherapeutic agent and siRNA for combination cancer therapy

B Xiao, L Ma, D Merlin - Expert opinion on drug delivery, 2017 - Taylor & Francis
… of chemotherapy and RNAi technology holds great promise as a new strategy for cancer
treatment. However, the chemotherapeutic agents and siRNAs … rather than miRNA and piRNA […

Nanocarrier-based co-delivery of small molecules and siRNA/miRNA for treatment of cancer

D Chitkara, S Singh, A Mittal - Therapeutic Delivery, 2016 - Taylor & Francis
chemotherapeutic agent could be delivered along with oligonucleotide/s (siRNA/miRNA)
to … Thus gene-based therapeutics in combination with potent chemotherapeutic agents is a …

Encapsulation of miRNA and siRNA into Nanomaterials for Cancer Therapeutics

M Zare, R Pemmada, M Madhavan, A Shailaja… - Pharmaceutics, 2022 - mdpi.com
… using siRNA, and hence the design of novel drugs, ie, cancer drugs in combination with
siRNA, … Nanoparticle platforms incorporating miRNA and chemotherapeutic drugs have been …

A double-modulation strategy in cancer treatment with a chemotherapeutic agent and siRNA

K Nakamura, ASA Lila, M Matsunaga, Y Doi, T Ishida… - Molecular Therapy, 2011 - cell.com
… , in which chemotherapy enhances intratumoral siRNA delivery and the delivered siRNA
Combination of siRNA-containing nanocarriers with chemotherapy may compensate for the …

[HTML][HTML] New paradigm in combination therapy of siRNA with chemotherapeutic drugs for effective cancer therapy

K Kumar, V Rani, M Mishra, R Chawla - Current Research in Pharmacology …, 2022 - Elsevier
miRNA (Micro RNA) miRNAs are single-stranded, non-coding RNA oligonucleotides (20–25
base pairs). Multiple siRNAs can be created from a single miRNA transcript. They target …

[HTML][HTML] Resistance to cancer chemotherapeutic drugs is determined by pivotal microRNA regulators

M Geretto, A Pulliero, C Rosano… - American journal of …, 2017 - ncbi.nlm.nih.gov
… Dicer in complex with different siRNA were solved [124]. A visual analysis of these structures
confirmed that the 2 nucleotide overhangs at the 3’ end of the siRNA are located in the PAZ …

[HTML][HTML] Nanocarrier-mediated co-delivery of chemotherapeutic drugs and gene agents for cancer treatment

L Kang, Z Gao, W Huang, M Jin, Q Wang - Acta Pharmaceutica Sinica B, 2015 - Elsevier
siRNA and miRNA can selectively knock down the carcinogenic genes by targeting specific
mRNAs. Therefore, combining chemotherapeutic drugs with gene agentsagents and drugs, …

Employing siRNA tool and its delivery platforms in suppressing cisplatin resistance: approaching to a new era of cancer chemotherapy

S Mirzaei, MH Gholami, F Hashemi, A Zabolian… - Life Sciences, 2021 - Elsevier
… of siRNA in suppressing cisplatin (CP) resistance in cancer. CP is a well-known chemotherapeutic
agent… factors including p15, p21, p27 and miRNA-218, while it reduces expressions of …