The Non-Coding RNA GAS5 and Its Role in Tumor Therapy-Induced Resistance

GI Lambrou, K Hatziagapiou, A Zaravinos - International journal of …, 2020 - mdpi.com
… is down-regulated in breast cancer tissues and linked to chemotherapy resistance [43]. …
the role of GAS5 in osteosarcoma with respect to chemotherapy-related resistance. However, …

Long noncoding RNA GAS5 inhibits malignant proliferation and chemotherapy resistance to doxorubicin in bladder transitional cell carcinoma

H Zhang, Y Guo, Y Song, C Shang - Cancer chemotherapy and …, 2017 - Springer
GAS5 regulated the chemotherapy resistanceGAS5 might act as a tumor-suppressing
gene in BTCC. However, none is known about the influence of GAS5 to chemotherapy resistance

Regulation of apoptosis by long non-coding RNA GAS5 in breast cancer cells: implications for chemotherapy

MR Pickard, GT Williams - Breast cancer research and treatment, 2014 - Springer
… expression may adversely impact upon the responses of breast cancer cells to certain
death-inducing stimuli, including conventional chemotherapeutic agents, and this resistance to …

[HTML][HTML] The essential role of long non-coding RNA GAS5 in glioma: interaction with microRNAs, chemosensitivity and potential as a biomarker

X Tan, H Jiang, Y Fang, D Han, Y Guo, X Wang… - Journal of …, 2021 - ncbi.nlm.nih.gov
GAS5 is a potential therapeutic target in glioma, and may be related to chemotherapy resistance
… , Akt, PI3K, and mTOR may be closely involved in chemotherapy resistance in glioma. …

Long non‑coding RNA GAS5 in human cancer

X Yang, Z Xie, X Lei, R Gan - Oncology letters, 2020 - spandidos-publications.com
… and chemotherapeutic drugs, while GAS5 downregulation attenuates these effects. … in
CC cells (65), while GAS5 overexpression increases the resistance of CC cells to cisplatin by …

Long non-coding RNA GAS5 inhibits DDP-resistance and tumor progression of epithelial ovarian cancer via GAS5-E2F4-PARP1-MAPK axis

X Long, K Song, H Hu, Q Tian, W Wang, Q Dong… - Journal of Experimental …, 2019 - Springer
… and drug resistance result in poor … chemotherapy, while statistical studies have shown that
about 15 to 25% of EOC patients appeared primary resistant to platinum-based chemotherapy

Long noncoding RNA GAS5 in breast cancer: epigenetic mechanisms and biological functions

EA Filippova, MV Fridman, AM Burdennyy… - International journal of …, 2021 - mdpi.com
… two commonly used clinical chemotherapy drugs that form complexes with GAS5, were
tested on TNBC cell lines [55]. The expression of GAS5 was increased in PTX-resistant MDA-231-…

Long noncoding RNA GAS5, which acts as a tumor suppressor via microRNA 21, regulates cisplatin resistance expression in cervical cancer

Q Wen, Y Liu, H Lyu, X Xu, Q Wu, N Liu, Q Yin… - International Journal of …, 2017 - ijgc.bmj.com
… To examine the effects of GAS5 expression on chemotherapeutic drug resistance, the
survival of CC cells transfected with lentivirus GAS5, GAS5 siRNAs, miR21 mimic, and miR-21 …

Long non‑coding RNA GAS5 is critical for maintaining stemness and induces chemoresistance in cancer stem‑like cells derived from HCT116

X Zhou, D Xiao - Oncology Letters, 2020 - spandidos-publications.com
… revealed that overexpression of GAS5 sensitized HCT116 cells to chemotherapeutic agents,
which … (miR)-21, which induced regulation of cisplatin resistance (21). In pancreatic cancer, …

Low GAS5 expression may predict poor survival and cisplatin resistance in cervical cancer

X Fang, G Zhong, Y Wang, Z Lin, R Lin, T Yao - Cell death & disease, 2020 - nature.com
… To prove that GAS5 regulated miR-21 as a competitive endogenous RNA (ceRNA), we used
… In summary, we confirmed that GAS5 was connected with prognosis and chemotherapeutic