… To test whether Shh has a role in growth control during chick wing digit-patterning, we treated
embryos at early bud stages Hamburger Hamilton stage 20 (HH20) with cyclopamine, an …

… digit fates—a process of digit specification that we suggest is … in patterning all vertebrate
limbs with more than three digits. … the chick wing polarizing region does not give rise to a digit …

… In summary, we have found molecular evidence of a digit I domain in the chicken wing that
is specified by early patterning mechanisms, but fails to undergo terminal differentiation. In …

… revealed a dorsal layer of the wing bud, in which almost all genes … those of genes implicated
in digit specification and Ptch1, 50 … to a network integrating digit specification and growth in …

… We also demonstrate how this timer restricts posterior digit development in the chick wing. In
… role in preventing digit development, while simultaneously specifying posterior digit identity. …

… The anterior to posterior sequence of digits and the overlying integument … wing bud tips
onto right chick wing bud stumps, we were also able to determine the contribution of host (chick) …

… the developing chick wing and specifying digit … digits over time, we compared 3 dimensional
(3D) expression patterns of these genes during wing development and related them to digit …

… to specify each wing digit is shown … specification of digit 3 requires 79 cells and digit 2, 35
cells. In one case, the transfer of only nine polarizing cells led to a wing with an additional digit …

… However, as four of the five digits of the mouse limb are … stage of chick wing development
results in a pattern of four digits, three … that the specification of the positional values of digits 1, 2 …

… phenotype Great progress has been made in understanding the specification of digit …
nondigit region on digit formation in chick wing bud. Development Dynamics, 233, 326-36. …